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dc.contributor.author
Coll, Carlos
dc.contributor.author
Fernandez, Ma. Alejandra
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Coll, Sebastián
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Coll, Tamara Anahí
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Malliardi, Pablo
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Perazzo, Juan Carlos
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Filinger, Ester Julia
dc.contributor.author
Lemberg, Abraham
dc.date.available
2017-02-20T21:00:32Z
dc.date.issued
2011-02
dc.identifier.citation
Coll, Carlos; Fernandez, Ma. Alejandra; Coll, Sebastián; Coll, Tamara Anahí; Malliardi, Pablo ; et al.; Effect of monocrotaline on blood brain barrier permeability in rats; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 2; 2-2011; 412-416
dc.identifier.issn
0326-2383
dc.identifier.uri
http://hdl.handle.net/11336/13193
dc.description.abstract
We studied if monocrotaline (MCT) portal hypertensive model modiies blood-brain barrier (BBB) condition. Male Wistar rats were used: Group MCT i.p. with MCT (60 mg/Kg of body weight) and Group Sham (GS) with saline. Forty-four days after injection rats were sacrified. Trypan blue and Evans blue tests were performed to evaluate BBB integrity in both groups. In cerebrospinal fluid (CF), protein and glucose were determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alcaline phsphatase were determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alcaline phosphatase were measured in serum samples. Portal pressure rose after MCT injection. Trypan blue diffused into hippocampus, Evans blue increased concentrations in brain of Group MCT and CT showed an increase in protein and glucose content in Group MCT. Serum AST, ALT and AP activities were significantly increase in Group MCT rats. It is suggested that liver damage and vasoconstrictor substances could produce portal hypertension, associated to toxic effects on brain and modifying thereby the BBB permeability
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Colegio Farmaceuticos Provincia de Buenos Aires
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Blood-Brain Barrier
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Liver Damage
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Monocrotaline
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Portal Hypertension
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of monocrotaline on blood brain barrier permeability in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-15T14:08:43Z
dc.journal.volume
30
dc.journal.number
2
dc.journal.pagination
412-416
dc.journal.pais
Argentina
dc.journal.ciudad
Buenos Aires
dc.description.fil
Fil: Coll, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
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Fil: Fernandez, Ma. Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
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Fil: Coll, Sebastián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
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Fil: Coll, Tamara Anahí. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Malliardi, Pablo . Hospital Thompson; Argentina
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Fil: Perazzo, Juan Carlos . Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Filinger, Ester Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Lemberg, Abraham . Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.journal.title
Latin American Journal of Pharmacy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=2
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