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dc.contributor.author
Moyano, M. A.  
dc.contributor.author
Segall, Adriana Ines  
dc.date.available
2017-02-20T21:00:17Z  
dc.date.issued
2011-07  
dc.identifier.citation
Moyano, M. A.; Segall, Adriana Ines; Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application; Society Of Cosmetic Chemists; Journal Of Cosmetic Science; 62; 4; 7-2011; 405-415  
dc.identifier.issn
1525-7886  
dc.identifier.uri
http://hdl.handle.net/11336/13190  
dc.description.abstract
Skin becomes thin, dry, pale, and fi nely wrinkled with age. Retinoids are a large class of compounds that are important in modern therapy for dermatological treatment of wrinkled skin. Of the retinoids, retinol and vitamin A palmitate are thought to induce thickening of the epidermis and to be effective for treatment of skin diseases. Accordingly, α-lipoic acid or the reduced form, dihydrolipoate, are potent scavengers of hydroxyl radicals, superoxide radicals, peroxyl radicals, singlet oxygen, and nitric oxide with anti-infl ammatory properties (1). Cosmetic ingredient stability prediction relies on kinetic quantitative chemical analysis of active components at different temperatures. Vitamin A palmitate and α-lipoic acid, are known to be unstable to light or heat (2). The aims of this study were to evaluate the stability of α-lipoic acid and vitamin A palmitate in the presence of vitamin E (acetate) and other antioxidants in lipophilic/hydrophilic medium (O/W emulsions) at pH 3.0, 5.0, and 7.0. The formulations that were investigated contained 0.12% (w/w) vitamin A palmitate, 0.4% (w/w) vitamin E acetate, and 0.5 % α-lipoic acid (formulation A), supplemented with ascorbyl palmitate, magnesium ascorbyl phosphate, and vitamin C (formulation B) or with butylhydroxytoluene (BHT, formulation C) or ascorbyl palmitate (formulation D). The chemical analyses of α-lipoic acid and vitamin A palmitate were carried out by HPLC. Formulations C and D at pH 7.0 were selected as the most stable for these components. The purpose of this paper is the selection of the most stable formulations for their application in in vivo studies.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society Of Cosmetic Chemists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Vitamin a Palmitate  
dc.subject
Lipoic Acid  
dc.subject
Stability  
dc.subject
Emulsions  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-02-15T14:08:39Z  
dc.journal.volume
62  
dc.journal.number
4  
dc.journal.pagination
405-415  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Moyano, M. A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.journal.title
Journal Of Cosmetic Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://library.scconline.org/v062n04/