Artículo
C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis
Aguirre, Florencia; Manin, Analisa; Fernandez, Victoria C.; Justo, Mariano Ezequiel
; Leoni, Juliana
; Paz, Mariela Laura
; Villa, Andres Maria
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Fecha de publicación:
08/2020
Editorial:
SAGE Publications
Revista:
Therapeutic Advances in Neurological Disorders
ISSN:
1756-2864
e-ISSN:
1756-2864
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as potential severity biomarkers in MG. Methods: Levels of C3, C4, C5a, and AChR-ab were measured in 60 AChR-ab-positive patients with MG. Their relationship with clinical severity was analyzed using the activities of daily living (ADL) and MG composite (MGC) scales. Results: AChR-ab titer correlated with severity of MG according to ADL (p = 0.002) and MGC scales (p = 0.001). When patients were classified according to disease duration, a statistically significant correlation between AChR-ab titer and clinical severity was only found in the subgroup of patients with fewer than 5 years from symptoms onset. C5a levels showed a positive correlation with MG severity according to the ADL scale (p = 0.041; τb = 0.18), although C5a levels were not different from the control group. Discussion: AChR-ab titers and C5a levels could potentially be considered markers of severity in patients with MG.
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Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Citación
Aguirre, Florencia; Manin, Analisa; Fernandez, Victoria C.; Justo, Mariano Ezequiel; Leoni, Juliana; et al.; C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis; SAGE Publications; Therapeutic Advances in Neurological Disorders; 13; 8-2020; 1-8
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