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dc.contributor.author
Polizio, Ariel Héctor
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dc.contributor.author
Chinchilla, Pilar
dc.contributor.author
Xiao, Chen
dc.contributor.author
Manning, David R.
dc.contributor.author
Riobo, Natalia
dc.date.available
2017-02-20T19:33:45Z
dc.date.issued
2011-11
dc.identifier.citation
Polizio, Ariel Héctor; Chinchilla, Pilar; Xiao, Chen; Manning, David R.; Riobo, Natalia; Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins; American Association For The Advancement Of Science; Science Signaling; 4; 200; 11-2011; 1-4
dc.identifier.issn
1937-9145
dc.identifier.uri
http://hdl.handle.net/11336/13180
dc.description.abstract
The vertebrate Hedgehog (Hh) pathway has essential functions during development and tissue homeostasis in normal physiology, and its dysregulation is a common theme in cancer. The Hh ligands (Sonic Hh, Indian Hh, and Desert Hh) bind to the receptors Patched1 and Patched2, resulting in inhibition of their repressive effect on Smoothened (Smo). Smo is a seven-transmembrane protein, which was only recently shown to function as a G protein–coupled receptor (GPCR) with specificity toward the heterotrimeric guanine nucleotide-binding protein Gi. In addition to activating Gi, Smo signals through its C-terminal tail to inhibit Suppressor of Fused, resulting in stabilization and activation of the Gli family of transcription factors, which execute a transcriptional response to so-called “canonical Hh signaling.” In this Presentation, we illustrate two outcomes of Hh signaling that are independent of Gli transcriptional activity and, thus, are defined as “noncanonical.” One outcome is dependent on Smo coupling to Gi proteins and exerts changes to the actin cytoskeleton through stimulation of the small guanosine triphosphatases (GTPases) RhoA and Rac1. These cytoskeletal changes promote migration in fibroblasts and tubulogenesis in endothelial cells. Signaling through the other noncanonical Hh pathway is independent of Smo and inhibits Patched1-induced cell death.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association For The Advancement Of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sonic Hedgehog
dc.subject
Migration
dc.subject
Non-Cannonical Pathway
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-15T14:08:19Z
dc.journal.volume
4
dc.journal.number
200
dc.journal.pagination
1-4
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Polizio, Ariel Héctor. Thomas Jefferson University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Chinchilla, Pilar. Thomas Jefferson University; Estados Unidos
dc.description.fil
Fil: Xiao, Chen. Thomas Jefferson University; Estados Unidos
dc.description.fil
Fil: Manning, David R.. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Riobo, Natalia. Thomas Jefferson University; Estados Unidos
dc.journal.title
Science Signaling
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://stke.sciencemag.org/content/4/200/pt7.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/scisignal.2002396
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