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dc.contributor.author
Guisoni, Nara Cristina
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dc.contributor.author
Mazzitello, Karina Irma
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dc.contributor.author
Diambra, Luis Anibal
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dc.date.available
2021-05-07T16:40:21Z
dc.date.issued
2020-06
dc.identifier.citation
Guisoni, Nara Cristina; Mazzitello, Karina Irma; Diambra, Luis Anibal; Alternating regimes of motion in a model with cell-cell interactions; American Physical Society; Physical Review E; 101; 6; 6-2020; 062408-18
dc.identifier.issn
2470-0045
dc.identifier.uri
http://hdl.handle.net/11336/131673
dc.description.abstract
Cellular movement is a complex dynamic process, resulting from the interaction of multiple elements at the intra-and extracellular levels. This epiphenomenon presents a variety of behaviors, which can include normal and anomalous diffusion or collective migration. In some cases, cells can get neighborhood information through chemical or mechanical cues. A unified understanding about how such information can influence the dynamics of cell movement is still lacking. In order to improve our comprehension of cell migration we have considered a cellular Potts model where cells move actively in the direction of a driving field. The intensity of this driving field is constant, while its orientation can evolve according to two alternative dynamics based on the Ornstein-Uhlenbeck process. In one case, the next orientation of the driving field depends on the previous direction of the field. In the other case, the direction update considers the mean orientation performed by the cell in previous steps. Thus, the latter update rule mimics the ability of cells to perceive the environment, avoiding obstacles and thus increasing the cellular displacement. Different cell densities are considered to reveal the effect of cell-cell interactions. Our results indicate that both dynamics introduce temporal and spatial correlations in cell velocity in a friction-coefficient and cell-density-dependent manner. Furthermore, we observe alternating regimes in the mean-square displacement, with normal and anomalous diffusion. The crossovers between diffusive and directed motion regimes are strongly affected by both the driving field dynamics and cell-cell interactions. In this sense, when cell polarization update grants information about the previous cellular displacement, the duration of the diffusive regime decreases, particularly in high-density cultures.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
POTTS MODEL
dc.subject
ACTIVE MATTER
dc.subject
CELL MOTILITY
dc.subject
ANOMALOUS DIFFUSION
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Alternating regimes of motion in a model with cell-cell interactions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-23T19:21:06Z
dc.journal.volume
101
dc.journal.number
6
dc.journal.pagination
062408-18
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Guisoni, Nara Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Mazzitello, Karina Irma. Universidad Nacional de Mar del Plata; Argentina
dc.description.fil
Fil: Diambra, Luis Anibal. Universidad Nacional de La Plata; Argentina
dc.journal.title
Physical Review E
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.aps.org/doi/10.1103/PhysRevE.101.062408
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1103/PhysRevE.101.062408
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