Synthesis and anticonvulsant activity of amino acid-derived sulfamides

Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).

Palabras clave: ANTICONVULSANT , SULFAMIDES , AMINOACIDS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/131303

URL: https://pubs.acs.org/doi/10.1021/jm800764p

DOI: http://dx.doi.org/10.1021/jm800764p

Colecciones

Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA

Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Gavernet, Luciana; Elvira, Juan E.; Samaja, Gisela Anabel; Pastore, Valentina; Cravero, Mariana Sella; et al.; Synthesis and anticonvulsant activity of amino acid-derived sulfamides; American Chemical Society; Journal of Medicinal Chemistry; 52; 6; 3-2009; 1592-1601

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