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dc.contributor.author
Landoni, Maria Fabiana
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dc.contributor.author
Albarellos, Gabriela Alejandra
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dc.date.available
2021-05-04T12:10:26Z
dc.date.issued
2018-10
dc.identifier.citation
Landoni, Maria Fabiana; Albarellos, Gabriela Alejandra; Pharmacokinetics of levofloxacin after single intravenous, oral and subcutaneous administration to dogs; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 42; 2; 10-2018; 171-178
dc.identifier.issn
0140-7783
dc.identifier.uri
http://hdl.handle.net/11336/131276
dc.description.abstract
The pharmacokinetic properties of the fluoroquinolone levofloxacin (LFX) were investigated in six dogs after single intravenous, oral and subcutaneous administration at a dose of 2.5, 5 and 5 mg/kg, respectively. After intravenous administration, distribution was rapid (T ½dist 0.127 ± 0.055 hr) and wide as reflected by the volume of distribution of 1.20 ± 0.13 L/kg. Drug elimination was relatively slow with a total body clearance of 0.11 ± 0.03 L kg −1 hr −1 and a T ½ for this process of 7.85 ± 2.30 hr. After oral and subcutaneous administration, absorption half-life and T max were 0.35 and 0.80 hr and 1.82 and 2.82 hr, respectively. The bioavailability was significantly higher (p ˂ 0.05) after subcutaneous than oral administration (79.90 vs. 60.94%). No statistically significant differences were observed between other pharmacokinetic parameters. Considering the AUC 24 hr /MIC and C max /MIC ratios obtained, it can be concluded that LFX administered intravenously (2.5 mg/kg), subcutaneously (5 mg/kg) or orally (5 mg/kg) is efficacious against Gram-negative bacteria with MIC values of 0.1 μg/ml. For Gram-positive bacteria with MIC values of 0.5 μg/kg, only SC and PO administration at a dosage of 5 mg/kg showed to be efficacious. MIC-based PK/PD analysis by Monte Carlo simulation indicates that the proposed dose regimens of LFX, 5 and 7.5 mg/kg/24 hr by SC route and 10 mg/kg/24 hr by oral route, in dogs may be adequate to recommend as an empirical therapy against S. aureus strains with MIC ≤ 0.5 μg/ml and E. coli strains with MIC values ≤0.125 μg/ml.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DOG
dc.subject
FLUOROQUINOLONES
dc.subject
LEVOFLOXACIN
dc.subject
PHARMACOKINETICS
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Pharmacokinetics of levofloxacin after single intravenous, oral and subcutaneous administration to dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:07:40Z
dc.journal.volume
42
dc.journal.number
2
dc.journal.pagination
171-178
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jvp.12726
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jvp.12726
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