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dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
dc.contributor.author
Raggio, Ignacio M.
dc.contributor.author
Deviggiano, Alejandro
dc.contributor.author
Bellia Munzon, Gastón
dc.contributor.author
Capunay, Carlos
dc.contributor.author
Nazar, Maximiliano
dc.contributor.author
Martinez, Jorge Luis
dc.contributor.author
Carrascosa, Patricia
dc.contributor.author
Martínez Ferro, Marcelo
dc.date.available
2021-04-28T11:30:21Z
dc.date.issued
2020-01
dc.identifier.citation
Rodriguez Granillo, Gaston Alfredo; Raggio, Ignacio M. ; Deviggiano, Alejandro; Bellia Munzon, Gastón; Capunay, Carlos; et al.; Impact of pectus excavatum on cardiac morphology and function according to the site of maximum compression: effect of physical exertion and respiratory cycle; Oxford University Press; European Heart Journal Cardiovascular Imaging; 21; 1; 1-2020; 44-84
dc.identifier.issn
2047-2412
dc.identifier.uri
http://hdl.handle.net/11336/130931
dc.description.abstract
Aims: Previous studies have demonstrated diverse cardiac manifestations in patients with pectus excavatum (PEX), although mostly addressing morphological or physiological impact as separate findings. Using multimodality imaging, we evaluated the impact of PEX on cardiac morphology and function according to the site of maximum compression, and the effect of exertion and breathing. Methods and results: All patients underwent chest computed tomography, cardiac magnetic resonance (CMR), and stress echocardiography (echo) in order to establish surgical candidacy. We evaluated diastolic function and trans-tricuspid gradient during stress (echo); and systolic function and respiratory-related septal wall motion abnormalities (CMR). Patients were classified according to the site of cardiac compression as type 0 (without cardiac compression); type 1 (right ventricle); and type 2 [right ventricle and atrioventricular (AV) groove]. Fifty-nine patients underwent multimodality imaging, with a mean age of 19.5 ± 5.9 years. Compared with a sex and age matched control group, peak exercise capacity was lower in patients with PEX (8.4 ± 2.0 METs vs. 15.1 ± 4.6 METs, P < 0.0001). At stress, significant differences were found between groups regarding left ventricular E/A (P = 0.004) and e/a ratio (P = 0.005), right ventricular E/A ratio (P = 0.03), and trans-tricuspid gradient (P = 0.001). At CMR, only 9 (15%) patients with PEX had normal septal motion, whereas 17 (29%) had septal flattening during inspiration. Septal motion abnormalities were significantly related to the cardiac compression classification (P < 0.0001). Conclusions: The present study demonstrated that patients with PEX, particularly those with compression affecting the right ventricle and AV groove, manifest diverse cardiac abnormalities that are mostly related to exertion, inspiration, and diastolic function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Haller index
dc.subject
cardiac magnetic resonance
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cardiopulmonary
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chest wall malformation
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Impact of pectus excavatum on cardiac morphology and function according to the site of maximum compression: effect of physical exertion and respiratory cycle
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T19:55:36Z
dc.identifier.eissn
2047-2412
dc.journal.volume
21
dc.journal.number
1
dc.journal.pagination
44-84
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional; Argentina
dc.description.fil
Fil: Raggio, Ignacio M.. No especifíca;
dc.description.fil
Fil: Deviggiano, Alejandro. No especifíca;
dc.description.fil
Fil: Bellia Munzon, Gastón. No especifíca;
dc.description.fil
Fil: Capunay, Carlos. No especifíca;
dc.description.fil
Fil: Nazar, Maximiliano. No especifíca;
dc.description.fil
Fil: Martinez, Jorge Luis. No especifíca;
dc.description.fil
Fil: Carrascosa, Patricia. No especifíca;
dc.description.fil
Fil: Martínez Ferro, Marcelo. No especifíca;
dc.journal.title
European Heart Journal Cardiovascular Imaging
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ehjcimaging/article/21/1/77/5425270
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ehjci/jez061
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