Evento

Binding of acidic PLA2 Ba SPII RP4 from Bothrops alternatus snake venom to integrin αvβ3: An in silico study

Angelina, Emilio LuisIcon ; Bustillo, Soledad; Bogado, Lucrecia; Garcia Denegri, María EmiliaIcon ; Peruchena, Nelida MariaIcon ; Leiva, Laura Cristina Ana
Tipo del evento: Congreso
Nombre del evento: 20th World Congress of the International Society on Toxinology
Fecha del evento: 09/2019
Institución Organizadora: International Society on Toxinology;
Título de la revista: Toxicon
Editorial: Elsevier
ISSN: 0041-0101
Idioma: Inglés
Clasificación temática:

Resumen

We have previously demonstrated that BaSpIIRP4 (an acidic PLA2 from Bothrops alternatus venom), enhance the endothelial cells (EC) detachment effect of a snake venom metalloproteinase. Considering that the binding of cells to their ligands depends on the interaction between extracellular matrix and integral membrane proteins, this effect may be due to interactions between PLA2 and EC integrins. The integrin alpha-v beta-3 (αvβ3) is commonly expressed in endothelial cells. It has been reported that human PLA2-IIA binds to this integrin with high affinity....
Palabras clave: ENDOTHELIAL CELLS , MOLECULAR DYNEMIC SIMULATIONS , RECEPTOR
 
Archivos asociados
Tamaño: 2.258Mb
Formato: PDF
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Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/130817
URL: https://www.sciencedirect.com/science/article/abs/pii/S0041010119308736
Colecciones
Eventos(CCT - NORDESTE)
Eventos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Eventos(IQUIBA-NEA)
Eventos de INSTITUTO DE QUIMICA BASICA Y APLICADA DEL NORDESTE ARGENTINO
Citación
Binding of acidic PLA2 Ba SPII RP4 from Bothrops alternatus snake venom to integrin αvβ3: An in silico study; 20th World Congress of the International Society on Toxinology; Buenos Aires; Argentina; 2019
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