Experimental gestational diabetes induces a pro-inflammatory and pro-oxidant environment in maternal and fetal livers

Abstract

Gestational diabetes (GDM) is a prevalent disease associated with a pro-oxidant and pro-inflammatory environment and with adverse consequences to both the mother and the offspring. The fetal liver is highly exposed to metabolic abnormalities, potentially leading to alterations in its development, which would affect the metabolic function in adulthood. The aim of this work was to evaluate whether pro-inflammatory and prooxidant markers are increased in maternal and fetal livers in GDM rats.