Genomic and phylogenetic analysis of hepatitis C virus isolates from Argentine patients: A six-year retrospective study

Typing of hepatitis C virus (HCV) isolates from Argentine patients was performed by using different methodologies in a population of 243 patients. HCV subtype was assigned based upon restriction fragment length polymorphism (RFLP). HCV RNA genomes obtained from serum samples were classified as belonging to clade 1 (53.5%), 2 (23.0%), or 3 (8.6%); 14.8% of samples showed HCV mixed infections, more frequently implying different subtypes within the same clade. In addition to RFLP typing, phylogenetic relatedness among sequences from both 5′ untranslated region (n = 50) and nonstructural 5B coding region (n = 15) was established.

Palabras clave: Hepatitis C virus , HCV genotypes , Argentina , Phylogenetic analysis

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/130328

URL: https://jcm.asm.org/content/38/12/4560.long

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC87637/

DOI: http://dx.doi.org/10.1128/JCM.38.12.4560-4568.2000

Colecciones

Articulos(CEMIC-CONICET)
Articulos de CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"

Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA

Citación

Quarleri, Jorge Fabian; Robertson, B.H.; Mathet, Veronica Lidia; Feld, Mariana; Espínola, Luis Alberto; et al.; Genomic and phylogenetic analysis of hepatitis C virus isolates from Argentine patients: A six-year retrospective study; American Society for Microbiology; Journal of Clinical Microbiology; 38; 12; 12-2000; 4560-4568

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