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dc.contributor.author
Fantilli, Anabella Clara
dc.contributor.author
Trinks, Julieta
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Marciano, Sebastian
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Zárate, Raúl Fabián
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Balderramo, Domingo
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Martínez Wassaf, Maribel G.
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Haddad, Leila
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Gadano, Adrián
dc.contributor.author
Debes, José D.
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Pisano, María Belén
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Ré, Viviana Elizabeth
dc.date.available
2021-04-19T03:44:03Z
dc.date.issued
2019-10-24
dc.identifier.citation
Fantilli, Anabella Clara; Trinks, Julieta; Marciano, Sebastian; Zárate, Raúl Fabián; Balderramo, Domingo; et al.; Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis; Public Library of Science; Plos One; 14; 10; 24-10-2019; 1-9
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/130275
dc.description.abstract
Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
HEV
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CIRRHOSIS
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ALCOHOL USE DISORDER
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ARGENTINA
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SEROPREVALENCE
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ALCOHOL-RELATED CIRRHOSIS
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-25T13:54:08Z
dc.journal.volume
14
dc.journal.number
10
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
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Fil: Marciano, Sebastian. Hospital Italiano; Argentina
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Fil: Zárate, Raúl Fabián. Hospital Córdoba; Argentina
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Fil: Balderramo, Domingo. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
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Fil: Martínez Wassaf, Maribel G.. LACE Laboratorios; Argentina
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Fil: Haddad, Leila. Hospital Italiano; Argentina
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Fil: Gadano, Adrián. Hospital Italiano; Argentina
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Fil: Debes, José D.. University of Minnesota; Estados Unidos
dc.description.fil
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pone.0224404
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224404
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