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dc.contributor.author Sesto Cabral, María Eugenia
dc.contributor.author Ramos Vernieri, Alberto Nicolás
dc.contributor.author Cabrera, Carla Agostina
dc.contributor.author Valdez, Juan Carlos
dc.contributor.author Gonzalez, Silvia Nelina
dc.date.available 2017-02-14T21:33:36Z
dc.date.issued 2015
dc.identifier.citation Sesto Cabral, María Eugenia; Ramos Vernieri, Alberto Nicolás; Cabrera, Carla Agostina; Valdez, Juan Carlos; Gonzalez, Silvia Nelina; Equipment and method for in vitro release measurements on topical dosage forms; Informa Healthcare; Pharmaceutical Development And Technology; 20; 5; -1-2015; 619-625
dc.identifier.issn 1083-7450
dc.identifier.uri http://hdl.handle.net/11336/13026
dc.description.abstract Context: In countries where research budgets are meager as Argentina, the tendency to innovation and improvements in the designs prototypes ‘‘made in Argentina’’ marks a growing trend adopted by researchers. This article presents a diffusion cell of original design, for release studies of Active Pharmaceutical Ingredient (API) from classical topical dosage forms, also includes the methodology for its optimization and validation. The objective was to evaluate and validate a system designed and to compare it to the Franz cells system. Methods: Parameters, reproducibility and robustness were performed included factors as, stirring conditions, membrane stabilization treatment and temperature variation. Release and retention on membrane assay were performed using two different API and formulations. Results: The method is reproducible and robust for the parameters tested. Release assays show that no significative difference with the Franz Cells system. Our system allows the simultaneous measurement of different parameters, representing an innovation on these methodologies. The LMC was used for assays of in vitro retention on membrane and the values obtained were reproducible and coincident whit values obtained for other authors. Conclusions: The system designed and the methodology employed, are acceptable for in vitro release studies. The device and method has the characteristics required.
dc.format application/pdf
dc.language.iso eng
dc.publisher Informa Healthcare
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject In vitro vertical diffusion cell
dc.subject Retention on membrane assay
dc.subject Residence time
dc.subject.classification Otras Ciencias de la Salud
dc.subject.classification Ciencias de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Equipment and method for in vitro release measurements on topical dosage forms
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-13T20:30:54Z
dc.identifier.eissn 1097-9867
dc.journal.volume 20
dc.journal.number 5
dc.journal.pagination 619-625
dc.journal.pais Suiza
dc.journal.ciudad Zug
dc.description.fil Fil: Sesto Cabral, María Eugenia. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Farmacia. Catedra de Tecnologia Farmaceutica Ii; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Ramos Vernieri, Alberto Nicolás. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Farmacia. Catedra de Tecnologia Farmaceutica Ii; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Cabrera, Carla Agostina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Farmacia. Catedra de Tecnologia Farmaceutica Ii; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Valdez, Juan Carlos. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Farmacia. Catedra de Tecnologia Farmaceutica Ii; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Gonzalez, Silvia Nelina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Microbiologia. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.journal.title Pharmaceutical Development And Technology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10837450.2014.908308
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10837450.2014.908308


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)