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dc.contributor.author
Arias, Bárbara Soledad
dc.contributor.author
Kovacec, Verónica Ivana
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Vigliarolo, Laura
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Suárez, Mariana
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Tersigni, Carina Laura
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Müller, Loana
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Lopardo, Horacio Angel
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Bonofiglio, Laura
dc.contributor.author
Mollerach, Marta Eugenia
dc.date.available
2021-04-16T13:37:53Z
dc.date.issued
2019-06
dc.identifier.citation
Arias, Bárbara Soledad; Kovacec, Verónica Ivana; Vigliarolo, Laura; Suárez, Mariana; Tersigni, Carina Laura; et al.; Fluoroquinolone-resistant streptococcus agalactiae invasive isolates recovered in Argentina; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 25; 5; 6-2019; 739-743
dc.identifier.issn
1076-6294
dc.identifier.uri
http://hdl.handle.net/11336/130190
dc.description.abstract
Background: Streptococcus agalactiae or group B Streptococcus (GBS) is an important pathogen in neonates and nonpregnant individuals. Epidemiological studies of GBS resistance to fluoroquinolones (FQs) in Latin America are scarce. This study aimed to determine the local prevalence of FQ resistance in the frame of a national, prospective multicenter study of invasive GBS infections and to investigate mechanisms of resistance, serotype distribution, and clonal relationships among resistant isolates. Methods: From July 2014 to July 2015, 162 invasive GBS isolates were collected from 86 health care centers in 32 Argentinean cities. All isolates were screened for FQ nonsusceptibility using a five-disc scheme: Levofloxacin (LVX), ciprofloxacin, norfloxacin (NOR), ofloxacin, and pefloxacin (PF). LVX minimal inhibitory concentration (MIC) was determined by the agar dilution method. Sequencing of internal regions of gyrA and parC genes was performed. Capsular typing and genetic characterization of nonsusceptible isolates were assessed by latex agglutination, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing. Results: Twenty-four of one hundred sixty-two GBS isolates exhibited no inhibition zones to all tested FQs with an MIC range of 16-32 mg/L for LVX, and one isolate with MIC = 1 mg/L showed no inhibition zones around NOR and PF discs. In all resistant isolates, point mutations were detected in both genes. Serotype Ib was prevalent (88%). One PFGE type accounted for 84% of the FQ-resistant isolates and belonged to serotype Ib, sequence type 10. Conclusions: The prevalence of FQ resistance was 14.8% likely to be associated with dissemination of an ST10/serotype Ib clone. The unexpected high rate of resistance emphasizes the relevance for continuous surveillance of GBS epidemiology and antibiotic susceptibility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBIOTIC RESISTANCE
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EPIDEMIOLOGY
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FLUOROQUINOLONES
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STREPTOCOCCUS AGALACTIAE
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Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Fluoroquinolone-resistant streptococcus agalactiae invasive isolates recovered in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T20:01:15Z
dc.journal.volume
25
dc.journal.number
5
dc.journal.pagination
739-743
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Arias, Bárbara Soledad. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Kovacec, Verónica Ivana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Vigliarolo, Laura. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
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Fil: Suárez, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
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Fil: Tersigni, Carina Laura. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
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Fil: Müller, Loana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
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Fil: Bonofiglio, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Microbial Drug Resistance: Mechanisms Epidemiology and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/mdr.2018.0246
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