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dc.contributor.author
Ardusso, Marina Silvana
dc.contributor.author
Manzo, Ruben Hilario
dc.contributor.author
Jimenez Kairuz, Alvaro Federico
dc.date.available
2021-04-12T20:16:06Z
dc.date.issued
2010-05
dc.identifier.citation
Ardusso, Marina Silvana; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico; Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100; Taylor & Francis Ltd; Supramolecular Chemistry; 22; 5; 5-2010; 289-296
dc.identifier.issn
1061-0278
dc.identifier.uri
http://hdl.handle.net/11336/129872
dc.description.abstract
A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium properties of dispersions of polymetacrylates Eudragit L 100, and Eudragit S 100, neutralized with increasing proportions of Lidocaine, Metoclopramide and Atenolol, were compared with those of Carbomer that were previously reported. The proportions of PE condensed (RCOO-DH+) and free species (D and DH+) were determined on PE-Lidocaine and PE-Metoclopramide systems. Affinity constants for ionic pair formation (Kip) were calculated as a function of D loading. In agreement with the high degree of counterionic condensation observed, the three (PE-D) complexes placed on Franz type cells released D at slow rates as water was the receptor medium. Rates increased over 3 times as water was replaced by 0.9% NaCl solution. Similar average of Korsmeyer exponent n (0.61 (water) and 0.69 (NaCl)) were found in both media. The overall kinetic behavior suggests that, under the conditions assayed, the dissociation of RCOO-DH+ is the factor that controls releasing rates. Structure related properties of the PE-D systems were identified in order to expand their potential uses as drug carriers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Polyelectrolyte-drug complexes
dc.subject
Ionic pairs
dc.subject
Affinity
dc.subject
Species distribution
dc.subject
Drug release
dc.subject.classification
Farmacología y Farmacia
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-09T16:18:36Z
dc.identifier.eissn
1029-0478
dc.journal.volume
22
dc.journal.number
5
dc.journal.pagination
289-296
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Ardusso, Marina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Manzo, Ruben Hilario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Supramolecular Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10610270903469757
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10610270903469757
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