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Artículo

Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation

Aiello, IgnacioIcon ; Mul Fedele, Malena LisIcon ; Román, F.; Marpegan, LucianoIcon ; Caldart Valle, Carlos SebastianIcon ; Chiesa, Juan JoséIcon ; Golombek, Diego AndrésIcon ; Finkielstein, C.V.; Paladino, NataliaIcon
Fecha de publicación: 10/2020
Editorial: Science Advances is the American Association for the Advancement of Science
Revista: Science Advances
ISSN: 2375-2548
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología

Resumen

Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic, and immune diseases, among others. Because outputs of the circadian clock regulate daily fluctuations in the immune response, we determined whether circadian disruption results in tumor-associated immune cell remodeling, facilitating tumor growth. Our findings show that tumor growth rate increased and latency decreased under circadian disruption conditions compared to normal light-dark (LD) schedules in a murine melanoma model. Circadian disruption induced the loss or inversion of daily patterns of M1 (proinflammatory) and M2 (anti-inflammatory) macrophages and cytokine levels in spleen and tumor tissues. Circadian disruption also induced (i) deregulation of rhythmic expression of clock genes and (ii) of cyclin genes in the liver, (iii) increased CcnA2 levels in the tumor, and (iv) dampened expression of the cell cycle inhibitor p21WAF/CIP1, all of which contribute to a proliferative phenotype.
Palabras clave: circadian , tumor , immune , cell cycle
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/129668
URL: https://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aaz4530
DOI: http://dx.doi.org/10.1126/sciadv.aaz4530
Colecciones
Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Aiello, Ignacio; Mul Fedele, Malena Lis; Román, F.; Marpegan, Luciano; Caldart Valle, Carlos Sebastian; et al.; Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 42; 10-2020; 1-13
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