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dc.contributor.author
Wirthmueller, Lennart
dc.contributor.author
Asai, Shuta
dc.contributor.author
Rallapalli, Ghanasyam
dc.contributor.author
Sklenar, Jan
dc.contributor.author
Fabro, Georgina
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dc.contributor.author
Kim, Dae Sung
dc.contributor.author
Lintermann, Ruth
dc.contributor.author
Jaspers, Pinja
dc.contributor.author
Wrzaczek, Michael
dc.contributor.author
Kangasjärvi, Jaakko
dc.contributor.author
MacLean, Daniel
dc.contributor.author
Menke, Frank L. H.
dc.contributor.author
Banfield, Mark J.
dc.contributor.author
Jones, Jonathan D. G.
dc.date.available
2021-04-08T19:44:05Z
dc.date.issued
2018-10
dc.identifier.citation
Wirthmueller, Lennart; Asai, Shuta; Rallapalli, Ghanasyam; Sklenar, Jan; Fabro, Georgina; et al.; Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to radical-induced cell death1; Wiley Blackwell Publishing, Inc; New Phytologist; 220; 1; 10-2018; 232-248
dc.identifier.issn
0028-646X
dc.identifier.uri
http://hdl.handle.net/11336/129657
dc.description.abstract
The oomycete pathogen Hyaloperonospora arabidopsidis (Hpa) causes downy mildew disease on Arabidopsis. To colonize its host, Hpa translocates effector proteins that suppress plant immunity into infected host cells. Here, we investigate the relevance of the interaction between one of these effectors, HaRxL106, and Arabidopsis RADICAL-INDUCED CELL DEATH1 (RCD1). We use pathogen infection assays as well as molecular and biochemical analyses to test the hypothesis that HaRxL106 manipulates RCD1 to attenuate transcriptional activation of defense genes. We report that HaRxL106 suppresses transcriptional activation of salicylic acid (SA)-induced defense genes and alters plant growth responses to light. HaRxL106-mediated suppression of immunity is abolished in RCD1 loss-of-function mutants. We report that RCD1-type proteins are phosphorylated, and we identified Mut9-like kinases (MLKs), which function as phosphoregulatory nodes at the level of photoreceptors, as RCD1-interacting proteins. An mlk1,3,4 triple mutant exhibits stronger SA-induced defense marker gene expression compared with wild-type plants, suggesting that MLKs also affect transcriptional regulation of SA signaling. Based on the combined evidence, we hypothesize that nuclear RCD1/MLK complexes act as signaling nodes that integrate information from environmental cues and pathogen sensors, and that the Arabidopsis downy mildew pathogen targets RCD1 to prevent activation of plant immunity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARABIDOPSIS THALIANA
dc.subject
HYALOPERONOSPORA ARABIDOPSIDIS
dc.subject
OOMYCETE PATHOGEN
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PATHOGEN EFFECTOR
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PLANT INNATE IMMUNITY
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RADICAL-INDUCED CELL DEATH1
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SALICYLIC ACID (SA)
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to radical-induced cell death1
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T19:36:14Z
dc.identifier.eissn
1469-8137
dc.journal.volume
220
dc.journal.number
1
dc.journal.pagination
232-248
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Wirthmueller, Lennart. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Asai, Shuta. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Rallapalli, Ghanasyam. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Sklenar, Jan. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Fabro, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.description.fil
Fil: Kim, Dae Sung. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Lintermann, Ruth. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Jaspers, Pinja. University of Helsinki; Finlandia
dc.description.fil
Fil: Wrzaczek, Michael. University of Helsinki; Finlandia
dc.description.fil
Fil: Kangasjärvi, Jaakko. University of Helsinki; Finlandia
dc.description.fil
Fil: MacLean, Daniel. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Menke, Frank L. H.. The Sainsbury Laboratory Norwich; Reino Unido
dc.description.fil
Fil: Banfield, Mark J.. John Innes Institute; Reino Unido
dc.description.fil
Fil: Jones, Jonathan D. G.. The Sainsbury Laboratory Norwich; Reino Unido
dc.journal.title
New Phytologist
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1111/nph.15277
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.15277
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