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dc.contributor.author
Anunziata, Florencia
dc.contributor.author
Macchione, Ana Fabiola
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Mitrano, Adriana Sofía
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D'aloisio, Génesis
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Ferreyra, Mirta Elena
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Pontoriero, Ricardo David
dc.contributor.author
Ahumada, Luis Alberto
dc.contributor.author
Molina, Juan Carlos
dc.date.available
2021-04-06T22:12:12Z
dc.date.issued
2020-08
dc.identifier.citation
Anunziata, Florencia; Macchione, Ana Fabiola; Mitrano, Adriana Sofía; D'aloisio, Génesis; Ferreyra, Mirta Elena; et al.; Respiratory and emotional reactivity to ethanol odor in human neonates is dependent upon maternal drinking patterns during pregnancy; Elsevier Ireland; Drug And Alcohol Dependence; 213; 108100; 8-2020; 1-41
dc.identifier.issn
0376-8716
dc.identifier.uri
http://hdl.handle.net/11336/129484
dc.description.abstract
Beyond the well-known deleterious effects of ethanol defining Fetal Alcohol Spectrum Disorders (FASD), the notion of fetal alcohol programming has gained scientific support. This phenomenon implies early neural plasticity relative to learning mechanisms comprising ethanol´s sensory cues and physiological effects of the drug; among others, its reinforcing properties and its depressant effects upon respiration. In this study, as a function of differential ethanol exposure during gestation, we analyzed neonatal physiological and behavioral responsiveness recruited by the odor of the drug.METHODSA factorial design defined by maternal ethanol intake during pregnancy (Low, n = 38; Moderate, n = 18 or High, n = 19) and olfactory stimulation (ethanol odor and/or or a novel scent) served as the basis of the study. Neonatal respiratory and cardiac frequencies, oxygen saturation levels and appetitive or aversive facial expressions, served as dependent variables.RESULTSNewborns of High drinkers exhibited significant physiological and behavioral signs indicative of alcohol odor recognition; specifically, respiratory depressions and exacerbated appetitive facial reactions coupled with diminished aversive expressions. Respiratory depressions were not accompanied by heart rate accelerations (cardiorespiratory dysautonomia). According to ROC curve analyses respiratory and behavioral reactivity were predictive of high maternal intake patterns.CONCLUSIONSThese results validate the notion of human fetal alcohol programming that is detected immediately after birth. The reported early functional signs indicative of relatively high alcohol gestational exposure should broaden our capability of diagnosing FASD and lead to appropriate primary or secondary clinical interventions (Registry of Health Research N.3201- RePIS, Córdoba, Argentina).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BREATHING PLASTICITY
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ETHANOL AFFINITY
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FACIAL EXPRESSIONS
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LEARNING AND MEMORY
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OLFACTORY DISCRIMINATION
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Respiratory and emotional reactivity to ethanol odor in human neonates is dependent upon maternal drinking patterns during pregnancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-02-18T16:44:18Z
dc.journal.volume
213
dc.journal.number
108100
dc.journal.pagination
1-41
dc.journal.pais
Irlanda
dc.description.fil
Fil: Anunziata, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Hospital Misericordia Nuevo Siglo; Argentina
dc.description.fil
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Mitrano, Adriana Sofía. Hospital Misericordia Nuevo Siglo; Argentina
dc.description.fil
Fil: D'aloisio, Génesis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Ferreyra, Mirta Elena. Hospital Misericordia Nuevo Siglo; Argentina
dc.description.fil
Fil: Pontoriero, Ricardo David. Hospital Misericordia Nuevo Siglo; Argentina
dc.description.fil
Fil: Ahumada, Luis Alberto. Hospital Misericordia Nuevo Siglo; Argentina
dc.description.fil
Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Hospital Misericordia Nuevo Siglo; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
dc.journal.title
Drug And Alcohol Dependence
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0376871620302659
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.drugalcdep.2020.108100
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