A neuroimaging study of functional connectivity during an emotion regulation task in major depressive disorder and borderline personality disorder

Abstract

One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is dysfunctional emotion regulation. Although these two conditions have been studied extensively in separate, it is not clear whether emotion regulation impairments are underpinned by shared neurobiological correlates. In the case of BPD, emotion regulation deficits relate to impulsivity, whereas MDD patients exhibit more frequent use of maladaptive strategies when regulating affect [1] and [2].