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dc.contributor.author
Plaza, Wladimir
dc.contributor.author
Gaschino, Felice
dc.contributor.author
Gutierrez, Camilo
dc.contributor.author
Santibañez, Nicolás
dc.contributor.author
Estay-Olmos, Camila
dc.contributor.author
Sotomayor-Zárate, Ramón
dc.contributor.author
De la Fuente-Ortega, Erwin
dc.contributor.author
Pautassi, Ricardo Marcos
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dc.contributor.author
Haeger, Paola A.
dc.date.available
2021-04-05T15:32:20Z
dc.date.issued
2020-05
dc.identifier.citation
Plaza, Wladimir; Gaschino, Felice; Gutierrez, Camilo; Santibañez, Nicolás; Estay-Olmos, Camila; et al.; Pre- and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption; John Wiley & Sons Inc; Developmental Psychobiology; 62; 4; 5-2020; 519-531
dc.identifier.issn
0012-1630
dc.identifier.uri
http://hdl.handle.net/11336/129369
dc.description.abstract
Repeated exposure to alcohol increases retrieval of fear-conditioned memories, which facilitates, among other factors, the emergence of post-traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague-Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose - sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3-4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long-term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALCOHOL USE DISORDER
dc.subject
AUDITORY FEAR MEMORY
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AVERSIVE MEMORY
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FETAL ALCOHOL SYNDROME
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POST-TRAUMATIC STRESS DISORDERS
dc.subject.classification
Drogadicción
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Pre- and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:19:05Z
dc.identifier.eissn
1098-2302
dc.journal.volume
62
dc.journal.number
4
dc.journal.pagination
519-531
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Plaza, Wladimir. Universidad Católica del Norte; Chile
dc.description.fil
Fil: Gaschino, Felice. Universidad Católica del Norte; Chile
dc.description.fil
Fil: Gutierrez, Camilo. Universidad de Valparaíso; Chile
dc.description.fil
Fil: Santibañez, Nicolás. Universidad de Valparaíso; Chile
dc.description.fil
Fil: Estay-Olmos, Camila. Universidad de Valparaíso; Chile
dc.description.fil
Fil: Sotomayor-Zárate, Ramón. Universidad de Valparaíso; Chile
dc.description.fil
Fil: De la Fuente-Ortega, Erwin. Universidad Católica del Norte; Chile
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Haeger, Paola A.. Universidad Católica del Norte; Chile
dc.journal.title
Developmental Psychobiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21925
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dev.21925
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