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dc.contributor.author
Cuggino, Julio César
dc.contributor.author
Strumia, Miriam Cristina
dc.contributor.author
Alvarez Igarzabal, Cecilia Ines
dc.date.available
2017-02-13T21:02:20Z
dc.date.issued
2011-04
dc.identifier.citation
Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-446
dc.identifier.issn
1381-5148
dc.identifier.uri
http://hdl.handle.net/11336/12934
dc.description.abstract
In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hydrogel Synthesis
dc.subject
Thermo-Sensitive Hydrogels
dc.subject
Drug Controlled Release
dc.subject
Corsslinked Strucutres
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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Biotecnología Industrial
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-09T13:51:55Z
dc.journal.volume
71
dc.journal.number
4
dc.journal.pagination
440-446
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
dc.description.fil
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
dc.description.fil
Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
dc.journal.title
Reactive & Functional Polymers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.reactfunctpolym.2011.01.002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514811000083
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