Artículo
Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis
Grotz, Estefanía
; Tateosian, Nancy Liliana
; Salgueiro, María Jimena; Bernabeu, Ezequiel Adrian
; Gonzalez, Lorena
; Manca, Maria Letizia; Amiano, Nicolás Oscar
; Valenti, Donatella; Manconi, Maria; García, Verónica Edith
; Moretton, Marcela Analía
; Chiappetta, Diego Andrés
Fecha de publicación:
10/2019
Editorial:
Editions Sante
Revista:
Journal of Drug Delivery Science and Technology
ISSN:
1773-2247
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Tuberculosis (TB) stands as the second “most deadly infectious disease” behind AIDS. Rifampicin (RIF) represents one of the most effective anti-TB drugs of the “short-term” oral TB therapy. However, the main limitations of the oral treatment are related with the lack of patient adherence and the development of multi-drug resistant Mycobacterium tuberculosis (Mtb) strains. Recently, the pulmonary administration of anti-TB drugs has become an attractive alternative to improve TB therapy. Hence, we have developed a respirable nanocarrier based on RIF-loaded polymeric micelles (PMs), employing a commercially available graft-copolymer of poly (vinyl caprolactam)-poly (vinyl acetate)-poly (ethylene glycol) (Soluplus). The RIF apparent aqueous solubility was increased (14.3-fold) and the micellar system was ranged in the nanoscale (~107 nm). Then, according to its in vitro aerodynamic behavior, our nanoformulation represented a suitable system for deep lung drug delivery. Interestingly, these inhalable RIF-loaded PMs enhanced (up to 2.5-fold) the in vitro drug microbicidal activity in Mtb-infected THP-1 macrophages versus a RIF solution. In addition, the biodistribution studies of the radiolabelled (99mTc) PMs demonstrated their lung accumulation over 24 hs in rats. Overall, this novel nanoformulation stands as an attractive platform for a potential inhalable TB therapy.
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Grotz, Estefanía; Tateosian, Nancy Liliana; Salgueiro, María Jimena; Bernabeu, Ezequiel Adrian; Gonzalez, Lorena; et al.; Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis; Editions Sante; Journal of Drug Delivery Science and Technology; 53; 10-2019; 1-10
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