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dc.contributor.author
Benedini, Luciano Alejandro
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dc.contributor.author
Andrés, Nancy Carolina
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dc.contributor.author
Fanani, Maria Laura
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dc.contributor.other
Pearson, Benjamin R.
dc.date.available
2021-04-01T12:38:31Z
dc.date.issued
2017
dc.identifier.citation
Benedini, Luciano Alejandro; Andrés, Nancy Carolina; Fanani, Maria Laura; Liposomes: From the pioneers to Epigenetic Therapy; Nova Science Publishers; 2017; 1-35
dc.identifier.isbn
978-1-53612-132-2
dc.identifier.uri
http://hdl.handle.net/11336/129312
dc.description.abstract
The nanoscience is the discipline that explains the behavior of systems at nanoscopicscale. The liposomes were one of the first nanostructures developed which were rapidlyapplied in different areas. These systems are structures formed by self-closingphospholipid bilayers in aqueous solutions. The strategies used for their developmenthave leaded them to reach a place of preponderance in drug delivery systems design.For analyzing the properties of liposomes, physicochemical concepts such as thoseused to describe liquid crystals, must be used. Owing to their amphiphilic nature, thephospholipids form aggregates giving an auspicious framework for the interaction withhydrophilic and lipophilic substances. These properties encouraged the emergence ofinnumerable modifications and thus, different types of liposomes have already beenreported since seventies to present. The main strategies have been focused on increasingtheir time of permanence in blood circulation and on decreasing their removal by the cellsof the mononuclear phagocyte system (MPS) in liver and spleen. For reaching this aimtheir size was reduced and their membrane fluidity was modified using cholesterol and sphingomyelins. However, one of the most successful strategies was the development ofPEGylated liposomes which have been named ?stealth liposomes.?Therefore, this book chapter is addressed to a comprehensive revision of thebibliography regarding to the emergence of liposomes and the first steps in their design,the type of systems (components and structures), their classification and properties.Their experimental physicochemical stability and also theoretical, using DLVOtheory, was analyzed. Furthermore, this text reviews some of the desired properties ofliposomes: the loading and the release of drugs, and their relationship with cells whichcan be mediated or not by receptors among other properties.The lipids, sterols, drugs or other different types of molecules which are able tointeract with the liposome membranes can be studied by biophysics techniques becausethey modify the self-organization at the air-water interface and the states of thesesystems. Therefore, this point is discussed in a separate section of this chapter.Finally, some approaches about the use of liposomes in the biomedicine field andapproved commercial formulations are revised. Additionally, some proposed perspectivesbased on their capability to carry molecules, such as silencing RNA (siRNA), which is astrategy used in pharmacoepigenetics therapy, are shown.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LIPOSOMES
dc.subject
EPIGENETIC
dc.subject
PERSPECTIVES
dc.subject.classification
Otras Nanotecnología
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Liposomes: From the pioneers to Epigenetic Therapy
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-05-11T14:48:31Z
dc.journal.pagination
1-35
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Benedini, Luciano Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Andrés, Nancy Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Fanani, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/liposomes-historical-clinical-and-molecular-perspectives/
dc.conicet.paginas
400
dc.source.titulo
Liposomes: Historical, clinical and molecular perspectives
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