Minimally disseminated disease and outcome in overt orbital retinoblastoma

In this retrospective study of patients with overt orbital retinoblastoma, we evaluated minimally disseminated disease (MDD) in bone marrow and cerebrospinal fluid (CSF) using CRX and/or GD2 synthase as markers. Ten patients were evaluated five (50%) at diagnosis and five upon relapse. MDD was detected in four cases (one in the bone marrow, two in the CSF, and in one case in both sites). All patients received chemotherapy and four received orbital radiotherapy. Seven patients relapsed or progressed and all of them died. Three patients remain in complete remission. There was no apparent correlation between MDD and the outcome.

Palabras clave: MINIMAL RESIDUAL DISEASE , MOLECULAR BIOLOGY , PEDIATRIC HEMATOLOGY/ONCOLOGY , RETINOBLASTOMA , TUMOR MARKERS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/129269

URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27662

DOI: http://dx.doi.org/10.1002/pbc.27662

Colecciones

Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Aschero, Rosario; Torbidoni, Ana Vanesa; Sampor, Claudia; Laurent, Viviana Eunice; Zugbi, Santiago; et al.; Minimally disseminated disease and outcome in overt orbital retinoblastoma; Veterinary and Human Toxicology; Pediatric Blood & Cancer; 66; 6; 6-2019; 1-5

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