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Artículo

Release of ATP by TRPV4 activation is dependent upon the expression of AQP2 in renal cells

Pizzoni, AlejandroIcon ; Bazzi, ZaherIcon ; Di Giusto, GiselaIcon ; Alvarez, Cora LiliaIcon ; Rivarola, ValeriaIcon ; Capurro, Claudia GracielaIcon ; Schwarzbaum, Pablo JulioIcon ; Ford, PaulaIcon
Fecha de publicación: 04/2021
Editorial: Wiley-liss, div John Wiley & Sons Inc.
Revista: Journal of Cellular Physiology
ISSN: 0021-9541
e-ISSN: 1097-4652
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Increasing evidence indicates that aquaporins (AQPs) exert an influence in cell signaling by the interplay with the transient receptor potential vanilloid 4 (TRPV4) channel. We previously found that TRPV4 physically and functionally interacts with AQP2 in cortical collecting ducts (CCD) cells, favoring cell volume regulation and cell migration. Because TRPV4 was implicated in ATP release in several tissues, we investigated the possibility that TRPV4/AQP2 interaction influences ATP release in CCD cells. Using two CCD cell lines expressing or not AQP2, we measured extracellular ATP (ATPe) under TRPV4 activation and intracellular Ca2+ under ATP addition. We found that AQP2 is critical for the release of ATP induced by TRPV4 activation. This ATP release occurs by an exocytic and a conductive route. ATPe, in turn, stimulates purinergic receptors leading to ATPe-induced ATP release by a Ca2+-dependent mechanism. We propose that AQP2 by modulating Ca2+ and ATP differently could explain AQP2-increased cell migration.
Palabras clave: AQUAPORIN-2 , ATP , CELL MIGRATION , PANNEXIN-1 , PURINERGIC RECEPTORS , TRPV4
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/129228
DOI: http://dx.doi.org/10.1002/jcp.30013
URL: https://onlinelibrary.wiley.com/doi/10.1002/jcp.30013
Colecciones
Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Pizzoni, Alejandro; Bazzi, Zaher; Di Giusto, Gisela; Alvarez, Cora Lilia; Rivarola, Valeria; et al.; Release of ATP by TRPV4 activation is dependent upon the expression of AQP2 in renal cells; Wiley-liss, div John Wiley & Sons Inc.; Journal of Cellular Physiology; 236; 4; 4-2021; 2559-2571
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