Artículo
Effect of Chlorpyrifos on human extravillous-like trophoblast cells
Ridano, Magali Evelin
; Racca, Ana Cristina
; Flores Martín, Jésica Belén
; Reyna, Luciana
; Genti de Raimondi, Susana
; Panzetta-Dutari, Graciela Maria del Valle
Fecha de publicación:
12/2019
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Reproductive Toxicology
ISSN:
0890-6238
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An increased risk of pregnancy disorders has been reported in women and animal models exposed to organophosphate pesticides. However, less information is available on impacts to human placental function. Here, we addressed the impact of chlorpyrifos (CPF) on extravillous cytotrophoblasts (evCTB) employing HTR8/SVneo cells as an in vitro model. Cell proliferation, migration and invasion were not affected by CPF under conditions where cell viability was not compromised; however, we observed reduced expression of genes for vascular endothelial growth factor receptor 1, hypoxia-inducible factor 1-alpha, peroxisome proliferator activated receptor gamma, and the β-subunit of human chorionic gonadotropin. These results are the first effects reported by organophosphate pesticide in evCTB cells and show altered expression of several genes important for placental development that could serve as potential biomarkers for future research.
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Ridano, Magali Evelin; Racca, Ana Cristina; Flores Martín, Jésica Belén; Reyna, Luciana; Genti de Raimondi, Susana; et al.; Effect of Chlorpyrifos on human extravillous-like trophoblast cells; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 90; 12-2019; 118-125
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