Mostrar el registro sencillo del ítem
dc.contributor.author
Sanchez, Angel Matias
dc.contributor.author
Flamini, Marina Ines
dc.date.available
2021-03-25T11:53:44Z
dc.date.issued
2012
dc.identifier.citation
Sanchez, Angel Matias; Flamini, Marina Ines; Rapid signaling of strogen to neuronal dendrite spine formation; Lambert Academic Publishing; 2012; 92
dc.identifier.isbn
978-3-8473-1746-3
dc.identifier.uri
http://hdl.handle.net/11336/128897
dc.description.abstract
Estrogens are important regulators of neuronal cell morphology and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by WAVE1 protein, which controls actin polymerization through the Arp-2/3 complex. We show that 17-estradiol (E2) administration leads to phosphorylation and redistribution of WAVE1 at sites of dendritic spine formation. WAVE1 phosphorylation is found to be triggered by a Galphai/Gbeta protein-dependent, rapid extranuclear signaling of ERalpha to Src/Rac1/Cdk5 that directly phosphorylates WAVE1. After WAVE1 phosphorylation, the Arp-2/3 complex concentrates at sites of spine formation, where it triggers the local reorganization of actin fibers. In parallel, E2 recruits a Galpha13-dependent pathway to RhoA and ROCK-2, leading to activation of actin remodeling via moesin. Silencing of WAVE1 or of moesin abrogates the increase in dendritic spines induced by E2. In conclusion, our findings indicate that the control of actin polymerization and branching via moesin or WAVE1 is a key function of ERalpha in neurons, which may be particularly relevant for the regulation of dendritic spines.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lambert Academic Publishing
dc.rights
info:eu-repo/semantics/closedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Estrogen
dc.subject
actin cytoskeleton
dc.subject
Spine density
dc.subject
WAVE1 and moesin
dc.subject
Neuronal plasticity
dc.subject
Neuroendocrinology
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Rapid signaling of strogen to neuronal dendrite spine formation
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/book
dc.type
info:ar-repo/semantics/libro
dc.date.updated
2020-08-04T20:07:49Z
dc.journal.pagination
92
dc.journal.pais
Alemania
dc.journal.ciudad
Saarbrücken
dc.description.fil
Fil: Sanchez, Angel Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Flamini, Marina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Archivos asociados
Tamaño:
14.76Mb
Formato:
PDF