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dc.contributor.author
Fuentes Castillo, Danny  
dc.contributor.author
Power, Pablo  
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Cerdeira, Louise  
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Cardenas-Arias, Adriana  
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Moura, Quézia  
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Oliveira, Flavio A.  
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Levy, Carlos E.  
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Gutkind, Gabriel Osvaldo  
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Catão-Dias, José L.  
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Lincopan, Nilton  
dc.date.available
2021-03-25T11:41:24Z  
dc.date.issued
2020-09  
dc.identifier.citation
Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; et al.; FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 9-2020; 1-5  
dc.identifier.issn
1076-6294  
dc.identifier.uri
http://hdl.handle.net/11336/128888  
dc.description.abstract
Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Mary Ann Liebert  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ESBL  
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BLAFONA-7  
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WILD BIRD  
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SOUTH AMERICA  
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Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-03-15T15:48:53Z  
dc.journal.pagination
1-5  
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Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Fuentes Castillo, Danny. Universidade de Sao Paulo; Brasil  
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Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
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Fil: Cerdeira, Louise. Universidade de Sao Paulo; Brasil  
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Fil: Cardenas-Arias, Adriana. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Moura, Quézia. Universidade de Sao Paulo; Brasil  
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Fil: Oliveira, Flavio A.. Universidade Estadual de Campinas; Brasil  
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Fil: Levy, Carlos E.. Universidade Estadual de Campinas; Brasil  
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Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Catão-Dias, José L.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil  
dc.journal.title
Microbial Drug Resistance: Mechanisms Epidemiology and Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2020.0061  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/mdr.2020.0061