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dc.contributor.author
Fuentes Castillo, Danny
dc.contributor.author
Power, Pablo
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Cerdeira, Louise
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Cardenas-Arias, Adriana
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Moura, Quézia
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Oliveira, Flavio A.
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Levy, Carlos E.
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Gutkind, Gabriel Osvaldo
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Catão-Dias, José L.
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Lincopan, Nilton
dc.date.available
2021-03-25T11:41:24Z
dc.date.issued
2020-09
dc.identifier.citation
Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; et al.; FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 9-2020; 1-5
dc.identifier.issn
1076-6294
dc.identifier.uri
http://hdl.handle.net/11336/128888
dc.description.abstract
Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ESBL
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BLAFONA-7
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WILD BIRD
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SOUTH AMERICA
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-15T15:48:53Z
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Fuentes Castillo, Danny. Universidade de Sao Paulo; Brasil
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Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
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Fil: Cerdeira, Louise. Universidade de Sao Paulo; Brasil
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Fil: Cardenas-Arias, Adriana. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Moura, Quézia. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Oliveira, Flavio A.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Levy, Carlos E.. Universidade Estadual de Campinas; Brasil
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Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Catão-Dias, José L.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil
dc.journal.title
Microbial Drug Resistance: Mechanisms Epidemiology and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2020.0061
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/mdr.2020.0061
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