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dc.contributor.author
Camarini, Rosana
dc.contributor.author
Hoffmann, Lucas Barbosa
dc.contributor.author
Suarez, Andrea
dc.contributor.author
Rae, Mariana
dc.contributor.author
Marcourakis, Tania
dc.contributor.author
Pautassi, Ricardo Marcos
dc.date.available
2021-03-24T15:03:16Z
dc.date.issued
2019-06
dc.identifier.citation
Camarini, Rosana; Hoffmann, Lucas Barbosa; Suarez, Andrea; Rae, Mariana; Marcourakis, Tania; et al.; Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 181; 6-2019; 60-68
dc.identifier.issn
0091-3057
dc.identifier.uri
http://hdl.handle.net/11336/128862
dc.description.abstract
Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine pretreatment during adolescence promotes the expression of behavioral sensitization to a greater extent than when the pretreatment occurs at adulthood. Behavioral sensitization has been associated to the transition from drug use to addiction and is postulated to indicate heightened sensitivity to the appetitive motivational effects of drugs. The relationship between behavioral sensitization and conventional measures of drug reward, such as conditioned place preference (CPP), has yet to be thoroughly investigated, and little is known about age-related differences in this phenomenon. The present study tested cocaine-induced CPP in adolescent and adult mice exposed to cocaine (or vehicle) pretreatment, either in an intermittent or “binge” (i.e., heavy cocaine use on a single occasion, which increases the likelihood of experiencing cocaine-related problems) fashion. Cocaine administration induced behavioral sensitization to a greater extent in adolescent than in adult mice. Cocaine-induced CPP was fairly similar in vehicle pretreated adolescent and adult mice, yet greater in adolescent vs. adults after cocaine-induced sensitization. The results confirmed the higher sensitivity of adolescent mice to cocaine-induced behavioral sensitization and suggest its association with greater sensitivity to cocaine's rewarding effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADOLESCENT
dc.subject
BINGE
dc.subject
COCAINE
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CONDITIONED PLACE PREFERENCE
dc.subject
SENSITIZATION
dc.subject.classification
Drogadicción
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:20:32Z
dc.journal.volume
181
dc.journal.pagination
60-68
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Camarini, Rosana. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil
dc.description.fil
Fil: Hoffmann, Lucas Barbosa. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil
dc.description.fil
Fil: Suarez, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Rae, Mariana. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil
dc.description.fil
Fil: Marcourakis, Tania. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.journal.title
Pharmacology Biochemistry and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0091305718306373
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pbb.2019.04.005
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