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dc.contributor.author
Gandasegui, Javier
dc.contributor.author
Martínez Valladares, María
dc.contributor.author
Grau Pujol, Berta
dc.contributor.author
Krolewiecki, Alejandro Javier
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dc.contributor.author
Balaña Fouce, Rafael
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Gelaye, Woyneshet
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Van Lieshout, Lisette
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Kepha, Stella
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Mandomando, Inácio
dc.contributor.author
Muñoz, José
dc.date.available
2021-03-24T02:10:46Z
dc.date.issued
2020-02-06
dc.identifier.citation
Gandasegui, Javier; Martínez Valladares, María; Grau Pujol, Berta; Krolewiecki, Alejandro Javier; Balaña Fouce, Rafael; et al.; Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials; Public Library of Science; Neglected Tropical Diseases; 14; 2; 6-2-2020; 1-7
dc.identifier.issn
1935-2735
dc.identifier.uri
http://hdl.handle.net/11336/128854
dc.description.abstract
More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO). WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment, etc) after years of mass drug-administration campaigns, which is one of the major concerns in STH control. Monitoring anthelmintic efficacy trials have been traditionally done by microscopic approaches, although it is well known that microscopy’s sensitivity may be insufficient in this context. We think that DNA-detection–based tools represent an accurate alternative to parasitological methods, and they should be evaluated and validated not only for monitoring worm burden before and after treatment but also for detecting genetic markers related to anthelmintic resistance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
MOLECULAR BIOLOGY
dc.subject
SOIL TRANSMITTED HELMINTHS
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NEGLECTED TROPICAL DISEASES
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DIAGNOSTICS
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DRUG RESISTANCE
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Tecnologías que involucran la identificación de ADN, proteínas y enzimas, y cómo influyen en el conjunto de enfermedades y mantenimiento del bienestar
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-05T18:32:58Z
dc.journal.volume
14
dc.journal.number
2
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Gandasegui, Javier. Universidad de Barcelona; España
dc.description.fil
Fil: Martínez Valladares, María. Instituto de Ganadería de Montaña; España. Universidad de León; España
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Fil: Grau Pujol, Berta. Universidad de Barcelona; España. Fundación Mundo Sano; Argentina
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Fil: Krolewiecki, Alejandro Javier. Universidad de Barcelona; España. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
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Fil: Balaña Fouce, Rafael. Universidad de León; España
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Fil: Gelaye, Woyneshet. Bahir Dar University; Etiopía
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Fil: Van Lieshout, Lisette. Leiden University. Leiden University Medical Center.; Países Bajos
dc.description.fil
Fil: Kepha, Stella. Kenya Medical Research Institute. Eastern and Southern Africa Centre of International Parasite Control; Kenia. London School of Hygiene and Tropical Medical Medicine. Faculty of Infectious and Tropical Diseases; Reino Unido. Pwani University; Kenia
dc.description.fil
Fil: Mandomando, Inácio. Centro de investigação de Saúde de Manhiça; Mozambique. Instituto Nacional de Saúde; Mozambique
dc.description.fil
Fil: Muñoz, José. Universidad de Barcelona; España
dc.journal.title
Neglected Tropical Diseases
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pntd.0007931
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info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007931
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/32027646/
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