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dc.contributor.author
Bekinschtein, Pedro Alejandro
dc.contributor.author
Oomen, Charlotte
dc.contributor.author
Saksida, Lisa M.
dc.contributor.author
Bussey, Timothy J.
dc.date.available
2017-02-10T20:36:28Z
dc.date.issued
2011-07
dc.identifier.citation
Bekinschtein, Pedro Alejandro; Oomen, Charlotte; Saksida, Lisa M.; Bussey, Timothy J.; Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?; Elsevier; Seminars In Cell & Developmental Biology; 22; 5; 7-2011; 536-542
dc.identifier.issn
1084-9521
dc.identifier.uri
http://hdl.handle.net/11336/12883
dc.description.abstract
Adult-generated neurons in the dentate gyrus of the hippocampus have been the focus of many studies concerned with learning and memory (L&M). It has been shown that procedures like environmental enrichment (EE) or voluntary physical exercise (Vex) can increase neurogenesis (NG) and also enhance L&M. It is tempting to conclude that improvements in L&M are due to the increased NG; that is, a causal relationship exists between enhancement of NG and enhancement of L&M. However, it remains unclear whether the L&M enhancement observed after these treatments is causally dependent on the increase in newborn neurons in the dentate gyrus. It remains a possibility that some unspecified change – a “third variable” – brought about by EE and/or Vex could be a causal determinant of both NG and L&M. We suggest that this third variable could be neurotrophic and/or plasticity-related factors such as BDNF. Indeed, both EE and Vex can induce expression of such proteins, and BDNF in particular has long been linked with L&M. In addition, we argue that a very likely source of variation in previous experiments was the load on “pattern separation”, a process that keeps similar memories distinct, and in which NG has been shown to be critically involved. To attempt to bring these ideas together, we present preliminary evidence that BDNF is also required for pattern separation, which strengthens the case for BDNF as a candidate third variable. Other ways in which BDNF might be involved are also discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Environmental Enrichment
dc.subject
Exercise
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Neurogenesis
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Bdnf
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Pattern Separation
dc.subject.classification
Otros Tópicos Biológicos
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-09T18:22:54Z
dc.journal.volume
22
dc.journal.number
5
dc.journal.pagination
536-542
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bekinschtein, Pedro Alejandro. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Oomen, Charlotte. University of Cambridge; Reino Unido
dc.description.fil
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
dc.journal.title
Seminars In Cell & Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1084952111000887
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.semcdb.2011.07.002


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