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dc.contributor.author Bekinschtein, Pedro Alejandro
dc.contributor.author Oomen, Charlotte
dc.contributor.author Saksida, Lisa M.
dc.contributor.author Bussey, Timothy J.
dc.date.available 2017-02-10T20:36:28Z
dc.date.issued 2011-07
dc.identifier.citation Bekinschtein, Pedro Alejandro; Oomen, Charlotte; Saksida, Lisa M.; Bussey, Timothy J.; Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?; Elsevier; Seminars In Cell & Developmental Biology; 22; 5; 7-2011; 536-542
dc.identifier.issn 1084-9521
dc.identifier.uri http://hdl.handle.net/11336/12883
dc.description.abstract Adult-generated neurons in the dentate gyrus of the hippocampus have been the focus of many studies concerned with learning and memory (L&M). It has been shown that procedures like environmental enrichment (EE) or voluntary physical exercise (Vex) can increase neurogenesis (NG) and also enhance L&M. It is tempting to conclude that improvements in L&M are due to the increased NG; that is, a causal relationship exists between enhancement of NG and enhancement of L&M. However, it remains unclear whether the L&M enhancement observed after these treatments is causally dependent on the increase in newborn neurons in the dentate gyrus. It remains a possibility that some unspecified change – a “third variable” – brought about by EE and/or Vex could be a causal determinant of both NG and L&M. We suggest that this third variable could be neurotrophic and/or plasticity-related factors such as BDNF. Indeed, both EE and Vex can induce expression of such proteins, and BDNF in particular has long been linked with L&M. In addition, we argue that a very likely source of variation in previous experiments was the load on “pattern separation”, a process that keeps similar memories distinct, and in which NG has been shown to be critically involved. To attempt to bring these ideas together, we present preliminary evidence that BDNF is also required for pattern separation, which strengthens the case for BDNF as a candidate third variable. Other ways in which BDNF might be involved are also discussed.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject Environmental enrichment
dc.subject Exercise
dc.subject Neurogenesis
dc.subject BDNF
dc.subject pattern separation
dc.subject.classification Otros Tópicos Biológicos
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-09T18:22:54Z
dc.journal.volume 22
dc.journal.number 5
dc.journal.pagination 536-542
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Bekinschtein, Pedro Alejandro. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil Fil: Oomen, Charlotte. University of Cambridge; Reino Unido
dc.description.fil Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
dc.description.fil Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
dc.journal.title Seminars In Cell & Developmental Biology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1084952111000887
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.semcdb.2011.07.002


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)