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dc.contributor.author
Flamini, Marina Ines
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dc.contributor.author
Sanchez, Angel Matias
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dc.contributor.author
Xiao Dong, Fu
dc.contributor.author
Simoncini, Tommaso
dc.contributor.other
Castoria, Gabriella
dc.contributor.other
Migliaccio, Antimo
dc.date.available
2021-03-23T10:35:22Z
dc.date.issued
2012
dc.identifier.citation
Flamini, Marina Ines; Sanchez, Angel Matias; Xiao Dong, Fu; Simoncini, Tommaso; Sex-steroid rapid action and its role in invasiveness and metastasis of breast cancer; Springer; 2012; 95-114
dc.identifier.isbn
978-1-4614-1763-7
dc.identifier.uri
http://hdl.handle.net/11336/128780
dc.description.abstract
Sex steroids, particularly estrogen and progesterone, promote normal breast tissue growth and differentiation. Prolonged exposure of estrogen and/or progesterone is well-documented to be the risk factor for breast cancer carcinogenesis, while the effects of sex steroids on breast cancer metastasis are controversial. Recent years emerging evidence indicate that sex steroids regulate the breast cancer metastatic processes via nongenomic and genomic mechanisms. Through nongenomic activation of actin-binding proteins, both estrogen and progesterone rapidly provoke actin cytoskeleton reorganization in breast cancer cells, leading to the formation of membrane specialized structures that facilitate breast cancer cell migration and invasion. Meanwhile, liganded-membrane steroid receptors interact and transactivate receptor tyrosine kinases (including epidermal growth factor receptor and insulin-like growth factor receptor), resulting in growth factor-like effects that transform cancer cell into an invasive phenotype. Moreover, sex steroids regulate the expression patterns of metastasis-associated molecules, such as cell adhesion molecule E-cadherin, matrix metalloproteinases, growth factors, chemokines and their receptors, leading to epithelial-to-mesenchymal-like transition and promoting breast cancer cells escape from primary site and migrate toward target tissues and organs. On the opposite, there is also evidence that sex steroids and their receptors protect against breast cancer cell invasiveness through distinct mechanisms. In this chapter, we present a brief overview of the molecular mechanisms of sex steroids on breast cancer metastasis and the understanding in this topic will be of most importance clinical therapies on breast cancer metastasis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sex Steroids
dc.subject
Estrogen and Progesterone
dc.subject
Metastasis
dc.subject
Breast Cancer
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sex-steroid rapid action and its role in invasiveness and metastasis of breast cancer
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-09-02T20:19:54Z
dc.journal.pagination
95-114
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Flamini, Marina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Sanchez, Angel Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Xiao Dong, Fu. Sun Yat-Sen University; China
dc.description.fil
Fil: Simoncini, Tommaso. University of Pisa; Italia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-4614-1764-4_6
dc.conicet.paginas
267
dc.source.titulo
Advances in rapid sex-steroid action: New Challenges and New Chances in Breast and Prostate Cancers
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