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dc.contributor.author
Peralta Ramos, Javier María
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dc.contributor.author
Iribarren, Pablo
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dc.contributor.author
Bousset, Luc
dc.contributor.author
Melki, Ronald
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Baekelandt, Veerle
dc.contributor.author
Van der Perren, Anke
dc.date.available
2021-03-19T21:01:45Z
dc.date.issued
2019-01
dc.identifier.citation
Peralta Ramos, Javier María; Iribarren, Pablo; Bousset, Luc; Melki, Ronald; Baekelandt, Veerle; et al.; Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration; Frontiers Media S.A.; Frontiers in Immunology; 10; JAN; 1-2019; 1-6
dc.identifier.uri
http://hdl.handle.net/11336/128718
dc.description.abstract
Innate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson´s disease (PD) and may contribute to the pathophysiology of the disease. The discovery of misfolded alpha-synuclein (αSYN) protein aggregates, which amplify in a ?prion-like? fashion, has led us to consider that pathogenic αSYN might be hijacking the activation and mobilization mechanism of the peripheral immune system to reach and disseminate within the CNS. Furthermore, our lab and other groups have recently shown that αSYN can adopt distinct fibril conformations or ?strains? with varying levels of pathogenic impact. Therefore, the aim of this study was to assess the impact of peripheral inflammation on αSYN spreading in order to better understand the participation of the immune system in the progression of PD. The results presented here show that intraperitoneal LPS injection prior to systemic intravenous recombinant administration of two different αSYN pathogenic strains (fibrils or ribbons) in wild type mice, induces an increase in brain resident microglia and promotes the recruitment of leukocytes toward the brain and the spinal cord. Our findings show for the first time that αSYN can be internalized by LPS-primed inflammatory monocytes, which in turn favors the dissemination from the periphery toward the brain and spinal cord. Further, we found a differential recruitment of CD4+ and CD8+ T cells after LPS priming and subsequent administration of the αSYN ribbons strain. Together, these data argue for a role of the peripheral immune system in αSYN pathology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media S.A.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALPHA-SYNUCLEIN
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INFLAMMATION
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INFLAMMATORY MONOCYTES
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PARKINSON'S DISEASE
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SYNUCLEINOPATHIES
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Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-25T17:52:00Z
dc.identifier.eissn
1664-3224
dc.journal.volume
10
dc.journal.number
JAN
dc.journal.pagination
1-6
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Peralta Ramos, Javier María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Iribarren, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Bousset, Luc. Institut François Jacob; Francia
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Fil: Melki, Ronald. Institut François Jacob; Francia
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Fil: Baekelandt, Veerle. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Van der Perren, Anke. Katholikie Universiteit Leuven; Bélgica
dc.journal.title
Frontiers in Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2019.00080
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2019.00080/full
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