Mostrar el registro sencillo del ítem
dc.contributor.author
Mishra, Anshuman
dc.contributor.author
Sundaravadivel, Pandarisamy
dc.contributor.author
Tripathi, Sunil Kumar
dc.contributor.author
Jha, Rajan Kumar
dc.contributor.author
Badrukhiya, Jaydeep
dc.contributor.author
Basak, Nipa
dc.contributor.author
Anerao, Isha
dc.contributor.author
Sharma, A. Surja
dc.contributor.author
Ajayi, Ebenezer Idowu O
dc.contributor.author
Mishra, Abhishek
dc.contributor.author
Pandey, Sonika
dc.contributor.author
Kumar, Umesh
dc.contributor.author
Singh, Sakshi
dc.contributor.author
Nizamuddin, Sheikh
dc.contributor.author
Tupperwar, Nitin C.
dc.contributor.author
Jha, Aditya Nath
dc.contributor.author
Thangaraj, Kumarasamy
dc.date.available
2021-03-19T21:00:48Z
dc.date.issued
2019-05
dc.identifier.citation
Mishra, Anshuman; Sundaravadivel, Pandarisamy; Tripathi, Sunil Kumar; Jha, Rajan Kumar; Badrukhiya, Jaydeep; et al.; Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India; Elsevier Ltd; Journal of Infection and Public Health; 12; 3; 5-2019; 380-387
dc.identifier.issn
1876-0341
dc.identifier.uri
http://hdl.handle.net/11336/128711
dc.description.abstract
The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
GENETIC POLYMORPHISM
dc.subject
INDIAN POPULATION
dc.subject
LEISHMANIA MAJOR, LEISHMANIA DONOVANI
dc.subject
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
dc.subject
VISCERAL LEISHMANIASIS (VL)
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:20:02Z
dc.identifier.eissn
1876-035X
dc.journal.volume
12
dc.journal.number
3
dc.journal.pagination
380-387
dc.journal.pais
Arabia Saudita
dc.description.fil
Fil: Mishra, Anshuman. Vinoba Bhave Research Institute; India. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Sundaravadivel, Pandarisamy. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Tripathi, Sunil Kumar. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Jha, Rajan Kumar. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Badrukhiya, Jaydeep. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Basak, Nipa. Academy Of Scientific And Innovative Research; India. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Anerao, Isha. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Sharma, A. Surja. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Ajayi, Ebenezer Idowu O. Centre For Cellular And Molecular Biology India; India. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Mishra, Abhishek. Institute Of Basic Sciences Agra; India
dc.description.fil
Fil: Pandey, Sonika. Banaras Hindu University; India
dc.description.fil
Fil: Kumar, Umesh. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Singh, Sakshi. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Nizamuddin, Sheikh. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Tupperwar, Nitin C.. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Jha, Aditya Nath. Sickle Cell Institute Chhattisgarh; India. Centre For Cellular And Molecular Biology India; India
dc.description.fil
Fil: Thangaraj, Kumarasamy. Centre For Cellular And Molecular Biology India; India
dc.journal.title
Journal of Infection and Public Health
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1876034118303435?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jiph.2018.12.011
Archivos asociados