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dc.contributor.author
Mingote, Evelin
dc.contributor.author
Meroño, Tomás
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dc.contributor.author
Rujelman, Rocío
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Marquez, Alejandra
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Fossati, Pia
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Gurfinkiel, Mirta
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Schnitman, Marta
dc.contributor.author
Brites, Fernando Daniel
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Faingold, Cristina
dc.contributor.author
Brenta, Gabriela
dc.date.available
2017-02-10T19:29:12Z
dc.date.issued
2012-07
dc.identifier.citation
Mingote, Evelin; Meroño, Tomás; Rujelman, Rocío; Marquez, Alejandra; Fossati, Pia; et al.; High TSH and low T4 as prognostic markers in older patients; Hellenic Endocrine Society; Hormone; 11; 3; 7-2012; 350-355
dc.identifier.issn
1109-3099
dc.identifier.uri
http://hdl.handle.net/11336/12867
dc.description.abstract
OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hellenic Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Elderly Patients
dc.subject
Hypothyroidism
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Hospitalization
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Non-Thyroidal Illness
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Thyroid Hormones
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Enfermedades Vasculares Periféricas
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
High TSH and low T4 as prognostic markers in older patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-09T18:22:39Z
dc.journal.volume
11
dc.journal.number
3
dc.journal.pagination
350-355
dc.journal.pais
Athens
dc.journal.ciudad
Greece
dc.description.fil
Fil: Mingote, Evelin. Hospital "Dr. César Milstein"; Argentina
dc.description.fil
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Rujelman, Rocío. Hospital "Dr. César Milstein"; Argentina
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Fil: Marquez, Alejandra. Hospital "Dr. César Milstein"; Argentina
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Fil: Fossati, Pia. Hospital "Dr. César Milstein"; Argentina
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Fil: Gurfinkiel, Mirta. Hospital "Dr. César Milstein"; Argentina
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Fil: Schnitman, Marta. Hospital "Dr. César Milstein"; Argentina
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Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Faingold, Cristina. Hospital "Dr. César Milstein"; Argentina
dc.description.fil
Fil: Brenta, Gabriela. Hospital "Dr. César Milstein"; Argentina
dc.journal.title
Hormone
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hormones.gr/814/article/article.html
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