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dc.contributor.author
Martínez, Gabriel  
dc.contributor.author
Ropero, Claudia  
dc.contributor.author
Funes, Andrea  
dc.contributor.author
Flores, Érica  
dc.contributor.author
Landa, Adriana I.  
dc.contributor.author
Gargiulo, Pascual Angel  
dc.date.available
2021-03-19T16:03:44Z  
dc.date.issued
2002-06  
dc.identifier.citation
Martínez, Gabriel; Ropero, Claudia; Funes, Andrea; Flores, Érica; Landa, Adriana I.; et al.; AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 76; 2; 6-2002; 205-212  
dc.identifier.issn
0031-9384  
dc.identifier.uri
http://hdl.handle.net/11336/128654  
dc.description.abstract
The effect of the blockade of N-methyl-D-aspartic acid (NMDA)-type glutamatergic receptors in the nucleus accumbens septi (Acc) during different phases of a passive avoidance task (step-through paradigm, two chambers) of learning was studied in male rats which had been bilaterally cannulated into the Acc. Animals were trained with a punishment procedure (3 s shock of 1 mA) to avoid one of the chambers. The rats received either saline or (±)2-amino-7-phosphonoheptanoic acid (AP-7) solution (1 μg/1 μl) 10 min before training (pretraining schedule) or immediately after the shock (posttraining schedule). In the test phase, the animals were placed back into the white chamber after 1 and 8 days later. In this moment, rats stayed there for 1 min, after which the time elapsed between the removal of the door to the introduction into the dark chamber of the head (Latency 1) and body (Latency 2) and fecal boli expelled were recorded. In the pretraining injection schedule, the drug treatment significantly reduced Latency 2 (P<.05) and fecal boli (P<0.01) on Day 1, and all parameters on Day 8 (P<.05). The posttraining injection schedule did not modify behavior. We conclude that a preshock NMDA-glutamatergic blockade of the Acc leads to cognitive disturbances during acquisition and a decrease in anxiety levels, but that the consolidation of a learned task is not affected by postshock administration.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ACCUMBENS  
dc.subject
ACQUISITION  
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COGNITION  
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GOAL-DIRECTED BEHAVIOR  
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NMDA-GLUTAMATERGIC TRANSMISSION  
dc.subject
PERCEPTION  
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SCHIZOPHRENIA  
dc.subject
WORKING MEMORY  
dc.subject.classification
Psiquiatría  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-01-18T15:47:52Z  
dc.journal.volume
76  
dc.journal.number
2  
dc.journal.pagination
205-212  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Martínez, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina  
dc.description.fil
Fil: Ropero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina  
dc.description.fil
Fil: Funes, Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina  
dc.description.fil
Fil: Flores, Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina  
dc.description.fil
Fil: Landa, Adriana I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina  
dc.description.fil
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina  
dc.journal.title
Physiology And Behavior  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/s0031-9384(02)00696-0  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0031938402006960