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dc.contributor.author
Leathwick, Dave M.  
dc.contributor.author
Miller, C.M.  
dc.contributor.author
Waghorn, Tania S.  
dc.contributor.author
Schwendel, Heike  
dc.contributor.author
Lifschitz, Adrian Luis  
dc.date.available
2021-03-18T14:32:21Z  
dc.date.issued
2020-12  
dc.identifier.citation
Leathwick, Dave M.; Miller, C.M.; Waghorn, Tania S.; Schwendel, Heike; Lifschitz, Adrian Luis; Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle; Elsevier; International Journal for Parasitology: Drugs and Drug Resistance; 14; 12-2020; 152-158  
dc.identifier.issn
2211-3207  
dc.identifier.uri
http://hdl.handle.net/11336/128517  
dc.description.abstract
An animal trial was conducted to measure the concentrations of ivermectin occurring in abomasal and small intestinal contents and mucosa, and in the target parasites (Ostertagia ostertagi and Cooperia oncophora) following administration by subcutaneous, oral and pour-on routes. Twenty-five steers were infected with ivermectin-resistant isolates of O. ostertagi and C. oncophora and following patency randomly allocated to 3 treatment groups of 7 and 1 untreated control group of four. On day 0, animals in the treatment groups were administered ivermectin via the oral, injectable or pour-on routes. On days 1, 2, 3, 4, 5, 6 and 8, blood samples were collected from all live animals, one animal from each treatment group was euthanised and the abomasum and small intestine recovered. Control animals were euthanised on each of days 4, 5, 6 and 8. Samples of gastrointestinal tract organs, their contents, mucosa and parasites were collected and assayed for ivermectin concentration using HPLC. The highest plasma concentrations occurred following subcutaneous administration. In the gastrointestinal contents the highest levels occurred following oral administration, although one high value occurred following pour-on administration, which was attributed to self-licking by the treated animal. The lowest GI content levels followed subcutaneous injection. Ivermectin concentrations in the gastrointestinal mucosa were highest following subcutaneous injection. Drug levels in the abomasal parasite O. ostertagi were most closely correlated with levels in the abomasal mucosa whereas levels in the intestinal C. oncophora were most closely correlated with those in the intestinal contents. Thus, the maximun levels of drug reached C. oncophora in the small intestine following oral administration. In contrast, the highest levels of ivermectin in O. ostertagi followed subcutaneous injection. Therefore, route of administration is likely to influence the exposure to ivermectin for different parasite species.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
CATTLE  
dc.subject
COOPERIA  
dc.subject
IVERMECTIN  
dc.subject
OSTERTAGIA  
dc.subject
PHARMACOLOGY  
dc.subject.classification
Ciencias Veterinarias  
dc.subject.classification
Ciencias Veterinarias  
dc.subject.classification
CIENCIAS AGRÍCOLAS  
dc.title
Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-03-15T14:33:06Z  
dc.journal.volume
14  
dc.journal.pagination
152-158  
dc.journal.pais
Australia  
dc.description.fil
Fil: Leathwick, Dave M.. Agresearch Grasslands Research Centre; Nueva Zelanda  
dc.description.fil
Fil: Miller, C.M.. Agresearch Grasslands Research Centre; Nueva Zelanda  
dc.description.fil
Fil: Waghorn, Tania S.. Agresearch Grasslands Research Centre; Nueva Zelanda  
dc.description.fil
Fil: Schwendel, Heike. Agresearch Grasslands Research Centre; Nueva Zelanda  
dc.description.fil
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
dc.journal.title
International Journal for Parasitology: Drugs and Drug Resistance  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijpddr.2020.10.006  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211320720300385#!