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Artículo

Protein misfolding, signaling abnormalities and altered fast axonal transport: Implications for Alzheimer and Prion diseases

Zamponi, EmilianoIcon ; Pigino, Gustavo FernandoIcon
Fecha de publicación: 07/2019
Editorial: Frontiers Media S.A.
Revista: Frontiers in Cellular Neuroscience
e-ISSN: 1662-5102
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Histopathological studies revealed that progressive neuropathies including Alzheimer, and Prion diseases among others, include accumulations of misfolded proteins intracellularly, extracellularly, or both. Experimental evidence suggests that among the accumulated misfolded proteins, small soluble oligomeric conformers represent the most neurotoxic species. Concomitant phenomena shared by different protein misfolding diseases includes alterations in phosphorylation-based signaling pathways synaptic dysfunction, and axonal pathology, but mechanisms linking these pathogenic features to aggregated neuropathogenic proteins remain unknown. Relevant to this issue, results from recent work revealed inhibition of fast axonal transport (AT) as a novel toxic effect elicited by oligomeric forms of amyloid beta and cellular prion protein PrPC, signature pathological proteins associated with Alzheimer and Prion diseases, respectively. Interestingly, the toxic effect of these oligomers was fully prevented by pharmacological inhibitors of casein kinase 2 (CK2), a remarkable discovery with major implications for the development of pharmacological target-driven therapeutic intervention for Alzheimer and Prion diseases.
Palabras clave: CASEIN KINASE 2 , FAST AXONAL TRANSPORT , KINESIN-1 , PRION PROTEIN , PROTEIN MISFOLDING , SIGNALING , SYNAPTIC DYSFUCTION
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/128428
URL: https://www.frontiersin.org/article/10.3389/fncel.2019.00350/full
DOI: http://dx.doi.org/10.3389/fncel.2019.00350
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Zamponi, Emiliano; Pigino, Gustavo Fernando; Protein misfolding, signaling abnormalities and altered fast axonal transport: Implications for Alzheimer and Prion diseases; Frontiers Media S.A.; Frontiers in Cellular Neuroscience; 13; 7-2019; 1-5
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