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dc.contributor.author
Ruiz, Maria Carolina
dc.contributor.author
Resasco, Agustina
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Di Virgilio, Ana Laura
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Ayala, Miguel
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Cavaco, Isabel
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Cabrera, Silvia
dc.contributor.author
Aleman, Jose
dc.contributor.author
León, Ignacio Esteban
dc.date.available
2021-03-15T15:14:56Z
dc.date.issued
2019-04
dc.identifier.citation
Ruiz, Maria Carolina; Resasco, Agustina; Di Virgilio, Ana Laura; Ayala, Miguel; Cavaco, Isabel; et al.; In vitro and in vivo anticancer effects of two quinoline–platinum(II) complexes on human osteosarcoma models; Springer; Cancer Chemotherapy And Pharmacology; 83; 4; 4-2019; 681-692
dc.identifier.issn
0344-5704
dc.identifier.uri
http://hdl.handle.net/11336/128329
dc.description.abstract
Platinum-based drugs, mainly cisplatin, are used for the treatment of several solid tumors such as OS. However, cisplatin treatment often results in the development of chemoresistance, leading therapeutic failure. We have previously reported that platinum complexes containing 8-hydroxyquinoline ligands have good antitumor activity against different cancer cell lines and with a different and better cytotoxic profile than cisplatin. Here, the anticancer properties of two different quinoline?platinum complexes [Pt(Cl) 2 (quinoline)(dmso)] (1) [PtCl(8-O-quinoline)(dmso)] (2) on in vitro (2D and 3D) and in vivo models (xenograft tumor of human osteosarcoma in mice) are presented. In this order, [PtCl(8-O-quinoline)(dmso)] (2) impaired cell viability to have a more pronounced antitumor effect than cisplatin on MG-63 osteosarcoma cells (IC 50 4 µM vs. 39 µM). Besides, [PtCl(8-O-quinoline)(dmso)] (2) increased ROS production in a dose-manner response and this compound induced early and late apoptotic fractions of human osteosarcoma cells. Finally, [PtCl(8-O-quinoline)(dmso)] (2) decreased the cell viability of multicellular spheroids and reduced the tumor volume on athymic nude mice N:NIH(S) Fox1 nu without inducing side effects. In this way, [PtCl(8-O-quinoline)(dmso)] (2) did not alter the normal cytoarchitecture of liver and kidney and the blood biomarkers (GPT, GOT, uremia, and creatinine) did not suffer modifications. Taken together, our data indicate that these compounds showed a better anticancer performance than cisplatin on in vitro and in vivo studies. These results showed the importance of chelation in the antitumor properties, suggesting that the [PtCl(8-O-quinoline)(dmso)] (2) might be a promising agent for the treatment of human osteosarcoma tumors resistant to cisplatin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
APOPTOSIS
dc.subject
OSTEOSARCOMA
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PLATINUM
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SPHEROIDS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
In vitro and in vivo anticancer effects of two quinoline–platinum(II) complexes on human osteosarcoma models
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-04T20:42:09Z
dc.journal.volume
83
dc.journal.number
4
dc.journal.pagination
681-692
dc.journal.pais
Alemania
dc.description.fil
Fil: Ruiz, Maria Carolina. Universidad Nacional de La Plata; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
dc.description.fil
Fil: Resasco, Agustina. Universidad Nacional de La Plata; Argentina. Universidad Nacional del La Plata. Facultad de veterinaria; Argentina
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Fil: Di Virgilio, Ana Laura. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
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Fil: Ayala, Miguel. Universidad Nacional de La Plata; Argentina
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Fil: Cavaco, Isabel. Universidad de Algarve; Portugal
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Fil: Cabrera, Silvia. Universidad Autónoma de Madrid; España
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Fil: Aleman, Jose. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: León, Ignacio Esteban. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.journal.title
Cancer Chemotherapy And Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00280-019-03773-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00280-019-03773-x
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