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dc.contributor.author
Ferrari, Luis Alberto
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dc.contributor.author
Arado, Miriam G.
dc.contributor.author
Nardo, Cesar A.
dc.contributor.author
Giannuzzi, Leda
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dc.date.available
2021-03-10T13:40:29Z
dc.date.issued
2003-04
dc.identifier.citation
Ferrari, Luis Alberto; Arado, Miriam G.; Nardo, Cesar A.; Giannuzzi, Leda; Post-mortem analysis of formic acid disposition in acute methanol intoxication; Elsevier Ireland; Forensic Science International; 133; 1-2; 4-2003; 152-158
dc.identifier.issn
0379-0738
dc.identifier.uri
http://hdl.handle.net/11336/127951
dc.description.abstract
Fifteen cases of fatal massive methanol intoxication have been investigated. Victims received either no treatment or ethanol therapeutic treatment. Methanol poisoning cases were classified in three groups according to survival time: more than 3 days (group 1), up to 3 days (group 2) and few hours (group 3). Body distribution of methanol and formic acid, as the main metabolite, was analyzed in blood and in different organs (brain, kidney, lung and liver). Relationships between formic acid concentration in the different tissues, survival time and type of treatment applied to victims were studied. Formic acid in blood and tissues was analyzed by head space gas chromatography (head space-GC) with FID detector, previous transformation in methyl formate, essentially as described by Abolin. Formic acid concentration was between 0.03 and 1.10g/l in the samples under study. A good correlation between blood and brain, but poor between blood and the remaining tissues was found. Obtained data suggested that the use of blood and brain could help to improve the analysis of formic acid intoxication. The best correlation among organs was found between lung and kidney for all groups (r2=0.91, 0.84 and 0.87, corresponding to groups 1, 2 and 3, respectively). Lethality index was defined as LI = (concentration of formic acid in blood in (g/l)/0.5) × 100, taking into account that 0.5g/l is the concentration reported by Mahieu in severe methanol poisoning. LI parameter was used to estimate formic acid incidence on the lethality of methanol poisoning cases. LI showed a good correlation with total formic acid concentration of the different tissues analyzed (r2=0.80). Furthermore, LI allowed us to discriminate between individuals that received therapeutic treatment and survived different periods. LI>100 indicated a severe intoxication and short survival time if the victim was assisted with ethanol therapy and hemodialysis was not applied. With regard to victims who received no therapeutic treatment and died in few hours, LI was in the range 40-100. LI was below 40 for individuals that survived more than 3 days and hemodyalisis was not performed. Results showed the importance of performing formic acid analysis to diagnose severe methanol intoxication in post-mortem cases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FORMIC ACID
dc.subject
METHANOL INTOXICATION
dc.subject
POISONING INDEX
dc.subject
POST-MORTEM ANALYSIS
dc.subject
TISSUE CONCENTRATION
dc.subject.classification
Otras Ciencias Naturales y Exactas
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dc.subject.classification
Otras Ciencias Naturales y Exactas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Post-mortem analysis of formic acid disposition in acute methanol intoxication
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-02-17T20:11:29Z
dc.identifier.eissn
1872-6283
dc.journal.volume
133
dc.journal.number
1-2
dc.journal.pagination
152-158
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Ferrari, Luis Alberto. Gobierno de la Provincia de Buenos Aires. Suprema Corte de Justicia de la Provincia de Buenos Aires.; Argentina. Universidad de Morón; Argentina
dc.description.fil
Fil: Arado, Miriam G.. Universidad de Morón; Argentina. Gobierno de la Provincia de Buenos Aires. Suprema Corte de Justicia de la Provincia de Buenos Aires.; Argentina
dc.description.fil
Fil: Nardo, Cesar A.. Gobierno de la Provincia de Buenos Aires. Suprema Corte de Justicia de la Provincia de Buenos Aires.; Argentina
dc.description.fil
Fil: Giannuzzi, Leda. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
dc.journal.title
Forensic Science International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://tinyurl.com/y7vwfd8a
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0379-0738(03)00071-9
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