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dc.contributor.author
Waxman Dova, Samanta
dc.contributor.author
Prados, Ana Paula
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De Lucas, José J.
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Wiemeyer, Guillermo
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Torres Bianchini, Laura
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San Andrés, Manuel
dc.contributor.author
Rodríguez, Casilda
dc.date.available
2021-03-10T03:39:55Z
dc.date.issued
2019-08
dc.identifier.citation
Waxman Dova, Samanta; Prados, Ana Paula; De Lucas, José J.; Wiemeyer, Guillermo; Torres Bianchini, Laura; et al.; Evaluation of allometric scaling as a tool for extrapolation of the enrofloxacin dose in American black vultures (Coragyps atratus); American Veterinary Medical Association; American Journal of Veterinary Research; 80; 8; 8-2019; 727-735
dc.identifier.issn
0002-9645
dc.identifier.uri
http://hdl.handle.net/11336/127890
dc.description.abstract
OBJECTIVE To determine the pharmacokinetics of enrofloxacin after IV administration in American black vultures (Coragyps atratus), to compare clearance of enrofloxacin in American black vultures with clearance of this fluoroquino-lone in other avian species, and to evaluate whether allometric scaling is an appropriate tool for dose extrapolation in avian species. ANIMALS 6 healthy adult American black vultures. PROCEDURES Enrofloxacin concentrations were quantified by use of high-performance liquid chromatography. Pharmacokinetics of enrofloxacin was determined in American black vultures after IV administration. Pharmacokinetic parameters for 12 avian species obtained from 24 pharmacokinetic studies were used. Allometric analysis of enrofloxacin pharmacokinetic parameters was performed. RESULTS Volume of distribution at steady state for enrofloxacin was 3.47 L/kg, clearance was 0.147 L/h•kg, and elimination half-life was 18.3 hours. Comparisons among avian species revealed that American black vultures had the lowest extraction ratio for enrofloxacin (1.04%). Only the volume of distribution at steady state and clearance had a good allometric fit. Goodness of fit was improved when ratites were not included in the analysis. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that the use of allometric scaling for the prediction of volume of distribution at steady state could provide a suitable method for extrapolation of enrofloxacin doses among avian species; however, allometric scaling could not be used to adequately predict the clearance of enrofloxacin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Veterinary Medical Association
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALLOMETRY
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ENROFLOXACIN
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AMERICAN BLACK VULTURES
dc.subject.classification
Ciencias Veterinarias
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Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Evaluation of allometric scaling as a tool for extrapolation of the enrofloxacin dose in American black vultures (Coragyps atratus)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-05T18:52:06Z
dc.journal.volume
80
dc.journal.number
8
dc.journal.pagination
727-735
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Schaumburg
dc.description.fil
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Cátedra de Anestesiología y Algiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Prados, Ana Paula. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
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Fil: De Lucas, José J.. Universidad Complutense de Madrid. Facultad de Veterinaria; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Wiemeyer, Guillermo. Jardín Zoológico de la Ciudad de Buenos Aires; Argentina. The Peregrine Fund; Estados Unidos. Fundación Caburé-í; Argentina
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Fil: Torres Bianchini, Laura. Jardín Zoológico de la Ciudad de Buenos Aires; Argentina
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Fil: San Andrés, Manuel. Universidad Complutense de Madrid. Facultad de Veterinaria; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rodríguez, Casilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Complutense de Madrid. Facultad de Veterinaria; España
dc.journal.title
American Journal of Veterinary Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.2460/ajvr.80.8.727
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://avmajournals.avma.org/doi/abs/10.2460/ajvr.80.8.727?journalCode=ajvr
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