Artículo
Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
Fecha de publicación:
05/2018
Editorial:
Elsevier Science Inc
Revista:
Steroids
ISSN:
0039-128X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action.
Palabras clave:
BREAST CANCER
,
PROGESTERONE RECEPTOR
,
REPRESSIVE ACTIONS
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Proietti Anastasi, Cecilia Jazmín; Cenciarini, Mauro Ezequiel; Elizalde, Patricia Virginia; Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions; Elsevier Science Inc; Steroids; 133; 5-2018; 75-81
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