Mostrar el registro sencillo del ítem
dc.contributor.author
Galvan, Estela Maria
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Nair, Manoj Kumar Mohan
dc.contributor.author
Chen, Huaiqing
dc.contributor.author
Del Piero, Fabio
dc.contributor.author
Schifferli, Dieter M.
dc.date.available
2017-02-08T21:52:28Z
dc.date.issued
2010-08
dc.identifier.citation
Galvan, Estela Maria; Nair, Manoj Kumar Mohan; Chen, Huaiqing; Del Piero, Fabio; Schifferli, Dieter M.; Biosafety level 2 model of pneumonic plague and protection studies with F1 and Psa; American Society For Microbiology; Infection And Immunity; 78; 8; 8-2010; 3443-3453
dc.identifier.issn
0019-9567
dc.identifier.uri
http://hdl.handle.net/11336/12782
dc.description.abstract
Attenuated Yersinia pestis pgm strains, such as KIM5, lack the siderophore yersiniabactin. Strain KIM5 does not induce significant pneumonia when delivered intranasally. In this study, mice were found to develop pneumonia after intranasal challenge with strain KIM5 when they were injected intraperitoneally with iron dextran, though not with iron sulfate. KIM5-infected mice treated daily with 4 mg iron dextran died in 3 days with severe pneumonia. Pneumonia was less severe if 4 mg iron dextran was administered only once before infection. The best-studied experimental vaccine against plague currently consists of the Yersinia pestis capsular antigen F1 and the type 3 secreted protein LcrV. The F1 antigen was shown to be protective against KIM5 infections in mice administered iron dextran doses leading to light or severe pneumonia, supporting the use of an iron dextran-treated model of pneumonic plague. Since F1 has been reported to be incompletely protective in some primates, and bacterial isolates lacking F1 are still virulent, there has been considerable interest in identifying additional protective subunit immunogens. Here we showed that the highly conserved Psa fimbriae of Y. pestis (also called pH 6 antigen) are expressed in murine organs after infection through the respiratory tract. Studies with iron dextran-treated mice showed that vaccination with the Psa fimbrial protein together with an adjuvant afforded incomplete but significant protection in the mouse model described. Therefore, further investigations to fully characterize the protective properties of the Psa fimbriae are warranted.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society For Microbiology
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Yersinia Pestis
dc.subject
Pneumonic Plague
dc.subject
Iron Dextran
dc.subject
Psa And F1
dc.subject.classification
Biología Celular, Microbiología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Biosafety level 2 model of pneumonic plague and protection studies with F1 and Psa
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-07T13:52:58Z
dc.journal.volume
78
dc.journal.number
8
dc.journal.pagination
3443-3453
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Galvan, Estela Maria. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. University of Pennsylvania School of Veterinary Medicine. Department of Pathobiology; Estados Unidos
dc.description.fil
Fil: Nair, Manoj Kumar Mohan. University of Pennsylvania School of Veterinary Medicine. Department of Pathobiology; Estados Unidos
dc.description.fil
Fil: Chen, Huaiqing. University of Massachusetts Medical School. Department of Medicine; Estados Unidos
dc.description.fil
Fil: Del Piero, Fabio. University of Pennsylvania School of Veterinary Medicine. Department of Pathobiology; Estados Unidos
dc.description.fil
Fil: Schifferli, Dieter M.. University of Pennsylvania School of Veterinary Medicine. Department of Pathobiology; Estados Unidos
dc.journal.title
Infection And Immunity
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/78/8/3443
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/IAI.00382-10
Archivos asociados