Mostrar el registro sencillo del ítem
dc.contributor.author
Díaz-García, Diana
dc.contributor.author
Ardiles, Perla R.
dc.contributor.author
Díaz-Sánchez, Miguel
dc.contributor.author
Mena-Palomo, Irene
dc.contributor.author
del Hierro, Isabel
dc.contributor.author
Prashar, Sanjiv
dc.contributor.author
Rodríguez-Diéguez, Antonio
dc.contributor.author
Páez, Paulina Laura
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Gómez Ruiz, Santiago
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2021-03-02T20:16:24Z
dc.date.issued
2020-02
dc.identifier.citation
Díaz-García, Diana; Ardiles, Perla R.; Díaz-Sánchez, Miguel; Mena-Palomo, Irene; del Hierro, Isabel; et al.; Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria; Elsevier Science Inc; Journal of Inorganic Biochemistry; 203; 110912; 2-2020
dc.identifier.issn
0162-0134
dc.identifier.uri
http://hdl.handle.net/11336/127186
dc.description.abstract
A series of copper-functionalized SBA-15 (Santa Barbara Amorphous) materials containing the ligands triethoxysilylpropylmaleamic acid (maleamic) or triethoxy-3-(2-imidazolin-1-yl)propylsilane (imidazoline) have been prepared. The nanostructured silica-based systems SBA-maleamic, SBA-imidazoline, SBA-maleamic-Cu and SBA-imidazoline-Cu were characterized by several methods observing that the functionalization took place mainly inside the pores of the mesoporous system. The antimicrobial behaviour of the synthesized materials against Staphylococcus aureus and Escherichia coli was tested observing a very potent activity of the copper-functionalized systems (minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for SBA-maleamic-Cu of ca. 31.25 μg/mL, which correspond with ca. 1.13 μg/mL of Cu). A study of the oxidative stress promoted by the synthesized materials showed that the SBA-maleamic-Cu and the SBA-imidazoline-Cu were able to increase the reactive oxygen species (ROS) production in S. aureus by 427% and 373%, respectively, while this increase was slightly lower in E. coli (387 and 324%, respectively). Furthermore, an electrochemical study was carried out in order to determine if these materials interact with lysine or alanine to validate a potential antimicrobial mechanism based on the inhibition of the synthesis of the peptidoglycan of the bacterial wall. Finally, these studies were also performed to determine the potential interaction of the copper-containing materials with glutathione in order to assess if they are able to perturb the metabolism of this tripeptide.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBACTERIAL ACTIVITY
dc.subject
COPPER
dc.subject
ELECTROCHEMISTRY
dc.subject
MESOPOROUS SILICA
dc.subject
ROS
dc.subject
SBA-15
dc.subject.classification
Otras Ciencias Químicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Químicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-04T18:14:22Z
dc.journal.volume
203
dc.journal.number
110912
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Díaz-García, Diana. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: Ardiles, Perla R.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
dc.description.fil
Fil: Díaz-Sánchez, Miguel. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: Mena-Palomo, Irene. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: del Hierro, Isabel. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: Prashar, Sanjiv. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: Rodríguez-Diéguez, Antonio. Universidad Rey Juan Carlos; España
dc.description.fil
Fil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; España
dc.journal.title
Journal of Inorganic Biochemistry
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0162013419304921
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jinorgbio.2019.110912
Archivos asociados