Artículo
Nanodelivery of nitazoxanide: Impact on the metabolism of Taenia crassiceps cysticerci intracranially inoculated in mice
Vinaud, Marina Claire; Real, Daniel Andres
; Fraga, Carolina Miguel; Lima, Nayana F.; Lino Junior, Ruy De Souza; Leonardi, Darío
; Salomon, Claudio Javier
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
05/2020
Editorial:
Future Medicine
Revista:
Therapeutic Delivery
ISSN:
2041-5990
e-ISSN:
2041-6008
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
To formulate nanocapsules and nanoemulsions of nitazoxanide (NTZ) and evaluate the metabolic effect on Taenia crassiceps cysticerci inoculated intracranially into mice. Materials & methods: NTZ nanosystems were formulated through solvent diffusion methodology. These nanoformulations were administered perorally and their impact on glycolysis, the tricarboxylic acid cycle and fatty acid metabolism in T. crassiceps cysticerci was investigated. Results: Gluconeogenesis and protein catabolism were significantly increased by the nanoformulations when compared with the control group and the NTZ-treated group. All the other metabolic pathways were inhibited by the nanoformulation treatments. Conclusion: The remarkable metabolic modifications that occur in this in vivo model through the application of these developed nanosystems confirm their capability to deliver NTZ into targeted tissues.
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Vinaud, Marina Claire; Real, Daniel Andres; Fraga, Carolina Miguel; Lima, Nayana F.; Lino Junior, Ruy De Souza; et al.; Nanodelivery of nitazoxanide: Impact on the metabolism of Taenia crassiceps cysticerci intracranially inoculated in mice; Future Medicine; Therapeutic Delivery; 11; 5; 5-2020; 329-339
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