Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.

Palabras clave: Vinylcaprolactam , HIV , Nanogels , Antiviral behavior

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/126889

URL: https://www.nature.com/articles/s41598-019-42150-9

DOI: http://dx.doi.org/10.1038/s41598-019-42150-9

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Articulos(IPQA)
Articulos deINSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS Y QUIMICA APLICADA

Citación

Macchione, Micaela Alejandra; Guerrero-Beltrán, Carlos; Rosso, Anabella Patricia; Euti, Esteban; Martinelli, Marisa; et al.; Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection; Nature Publishing Group; Scientific Reports; 9; 1; 12-2019; 1-10

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