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dc.contributor.author
Mocayar Maron, Feres Jose
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dc.contributor.author
Ferder, Leon Fernando
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dc.contributor.author
Reiter, Russel
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dc.contributor.author
Manucha, Walter Ariel Fernando
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dc.date.available
2021-02-26T16:39:16Z
dc.date.issued
2020-05
dc.identifier.citation
Mocayar Maron, Feres Jose; Ferder, Leon Fernando; Reiter, Russel; Manucha, Walter Ariel Fernando; Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin; Pergamon-Elsevier Science Ltd; Journal of Steroid Biochemistry and Molecular Biology; 199; 5-2020; 1-11
dc.identifier.issn
0960-0760
dc.identifier.uri
http://hdl.handle.net/11336/126798
dc.description.abstract
From an evolutionary point of view, vitamin D and melatonin appeared very early and share functions related to defense mechanisms. In the current clinical setting, vitamin D is exclusively associated with phosphocalcic metabolism. Meanwhile, melatonin has chronobiological effects and influences the sleep-wake cycle. Scientific evidence, however, has identified new actions of both molecules in different physiological and pathological settings. The biosynthetic pathways of vitamin D and melatonin are inversely related relative to sun exposure. A deficiency of these molecules has been associated with the pathogenesis of cardiovascular diseases, including arterial hypertension, neurodegenerative diseases, sleep disorders, kidney diseases, cancer, psychiatric disorders, bone diseases, metabolic syndrome, and diabetes, among others. During aging, the intake and cutaneous synthesis of vitamin D, as well as the endogenous synthesis of melatonin are remarkably depleted, therefore, producing a state characterized by an increase of oxidative stress, inflammation, and mitochondrial dysfunction. Both molecules are involved in the homeostatic functioning of the mitochondria. Given the presence of specific receptors in the organelle, the antagonism of the renin-angiotensin-aldosterone system (RAAS), the decrease of reactive species of oxygen (ROS), in conjunction with modifications in autophagy and apoptosis, anti-inflammatory properties inter alia, mitochondria emerge as the final common target for melatonin and vitamin D. The primary purpose of this review is to elucidate the common molecular mechanisms by which vitamin D and melatonin might share a synergistic effect in the protection of proper mitochondrial functioning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LIGHT/DARK CYCLE
dc.subject
MELATONIN
dc.subject
MITOCHONDRIA
dc.subject
OXIDATIVE STRESS
dc.subject
VDR
dc.subject
VITAMIN D
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-04T19:38:13Z
dc.journal.volume
199
dc.journal.pagination
1-11
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Mocayar Maron, Feres Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Ferder, Leon Fernando. University of Miami; Estados Unidos
dc.description.fil
Fil: Reiter, Russel. University of Texas at San Antonio; Estados Unidos
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Journal of Steroid Biochemistry and Molecular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960076019305990
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jsbmb.2020.105595
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