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dc.contributor.author
Ferramola, Florencia Fátima
dc.contributor.author
Dávila, Silvia del Valle
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Sasso, Corina Verónica
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Mattar Domínguez, María Aída
dc.date.available
2021-02-26T16:36:25Z
dc.date.issued
2020-01
dc.identifier.citation
Ferramola, Florencia Fátima; Dávila, Silvia del Valle; Sasso, Corina Verónica; Mattar Domínguez, María Aída; Molecular mimicry between Larrea divaricata Cav. plant and a reference strain of Pseudomonas aeruginosa; Academic Press Ltd - Elsevier Science Ltd; Microbial Pathogenesis; 138; 103818; 1-2020; 1-7
dc.identifier.issn
0882-4010
dc.identifier.uri
http://hdl.handle.net/11336/126797
dc.description.abstract
Currently, the world health sector faces a big problem due to the increase of bacterial strains resistant to antibiotics. In 2017, the World Health Organization reported a list of resistant bacteria, among which Pseudomonas aeruginosa was present. This opportunistic pathogen is associated to nosocomial infections, and no effective vaccines against this bacterium have been found. Larrea divaricata Cav. (jarilla) is a shrub highly distributed in America and widely used in folk medicine. In our laboratory, cross-reactivity of antibodies obtained from the recognition of jarilla proteins against proteins from gram-negative bacteria has been demonstrated. The objective of this study was to study the cross-reactivity of anti-L. divaricata antibodies with P. aeruginosa extracellular proteins in order to find an innocuous prophylactic therapy against this nosocomial pathogen. We observed that antibodies generated by proteins from jarilla crude extract recognized antigenic determinants present in extracellular proteins of P. aeruginosa. However, further studies are needed to investigate the neutralizing capacity of these antibodies on the specific enzymatic proteins involved in the pathogenicity of this bacterium.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Ltd - Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AQUEOUS EXTRACT
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CROSS-REACTIVITY
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ISMMUNOGENIC PROTEINS
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LARREA DIVARICATA
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PSEUDOMONAS AERUGINOSA
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Molecular mimicry between Larrea divaricata Cav. plant and a reference strain of Pseudomonas aeruginosa
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-04T19:38:01Z
dc.journal.volume
138
dc.journal.number
103818
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ferramola, Florencia Fátima. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dávila, Silvia del Valle. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
dc.description.fil
Fil: Sasso, Corina Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Mattar Domínguez, María Aída. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
dc.journal.title
Microbial Pathogenesis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S088240101930748X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.micpath.2019.103818
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