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dc.contributor.author Centanin, Lázaro
dc.contributor.author Gorr, Thomas A
dc.contributor.author Wappner, Pablo
dc.date.available 2017-02-07T17:10:01Z
dc.date.issued 2010-05
dc.identifier.citation Centanin, Lázaro; Gorr, Thomas A; Wappner, Pablo; Tracheal remodelling in response to hypoxia; Elsevier Science; Journal Of Insect Physiology; 56; 5; 5-2010; 447-454
dc.identifier.issn 0022-1910
dc.identifier.uri http://hdl.handle.net/11336/12643
dc.description.abstract The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject Tracheae
dc.subject Plasticity
dc.subject Hypoxia
dc.subject Cell autonomy
dc.subject.classification Biología del Desarrollo
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Tracheal remodelling in response to hypoxia
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-07T13:53:05Z
dc.journal.volume 56
dc.journal.number 5
dc.journal.pagination 447-454
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Centanin, Lázaro. University of Heidelberg. Institute of Zoology; Alemania. Fundación Instituto Leloir; Argentina
dc.description.fil Fil: Gorr, Thomas A. University of Zúrich. Institute of Veterinary Physiology; Suiza. Fundación Instituto Leloir; Argentina
dc.description.fil Fil: Wappner, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
dc.journal.title Journal Of Insect Physiology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022191009002212
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jinsphys.2009.05.008


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)