Show simple item record

dc.contributor.author Mathieu, Patricia Andrea
dc.contributor.author Piantanida, Ana Paula
dc.contributor.author Pitossi, Fernando Juan
dc.date.available 2017-02-07T15:33:29Z
dc.date.issued 2010
dc.identifier.citation Mathieu, Patricia Andrea; Piantanida, Ana Paula; Pitossi, Fernando Juan; Chronic expression of transforming growth factor-beta enhances adult neurogenesis; Karger; Neuroimmunomodulation.; 17; 3; -1-2010; 200-201
dc.identifier.issn 1021-7401
dc.identifier.uri http://hdl.handle.net/11336/12637
dc.description.abstract Neural stem cells reside in two neurogenic regions of the adult brain: the dentate gyrus of the hippocampus (DG) and the subventricular zone (SVZ). Their proliferation, differentiation, migration and survival are modulated by intrinsic and extrinsic signals, forming a neurogenic niche. Brain cytokines have only been recently regarded as possible components of this neurogenic niche. In particular, we have demonstrated that transforming growth factor-beta (TGF-beta) has a pro-neurogenic effect in the DG in a model of increased neurogenesis by adrenalectomy. We wanted to test whether TGF-beta has a similar effect in another neurogenic region, namely the SVZ. To test this possibility, adult rats were injected with adenoviral vectors expressing TGF-beta (Ad-TGF) or beta-galactosidase (Ad-bgal) in the SVZ and neurogenesis was evaluated 3 weeks later. We have observed that chronic TGF-beta expression increased neurogenesis in the ipsilateral hemisphere of Ad-TGF but not in Ad-bgal-treated rats compared to their contralateral side. In addition, an unspecific effect of the adenoviral vector per se could not be totally discarded. We conclude, under our experimental conditions, that TGF-beta could enhance adult neurogenesis in the SVZ. This data increase the growing evidence supporting a pro-neurogenic role of anti-inflammatory cytokines in the adult brain.
dc.format application/pdf
dc.language.iso eng
dc.publisher Karger
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject TGF-BETA
dc.subject NEUROGENESIS
dc.subject ADENOVIRUS
dc.subject INFLAMMATION
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Chronic expression of transforming growth factor-beta enhances adult neurogenesis
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-07T13:53:17Z
dc.journal.volume 17
dc.journal.number 3
dc.journal.pagination 200-201
dc.journal.pais Suiza
dc.description.fil Fil: Mathieu, Patricia Andrea. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil Fil: Piantanida, Ana Paula. Fundación Instituto Leloir; . Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
dc.description.fil Fil: Pitossi, Fernando Juan. Fundación Instituto Leloir; . Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
dc.journal.title Neuroimmunomodulation.
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/258723
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000258723


Archivos asociados

Icon
Blocked Acceso no disponible

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)